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@MASTERSTHESIS{Thai:182522,
      author       = {L. H. Thai$^*$},
      title        = {{X}-{R}ay {M}inibeams - {D}osimetry {A}nd {I}n {V}itro
                      {E}ffects {O}n{H}460 {L}ung {C}ancer {C}ells},
      school       = {Universität Heidelberg},
      type         = {Bachelorarbeit},
      reportid     = {DKFZ-2022-02714},
      year         = {2022},
      note         = {Bachelorarbeit, Universität Heidelberg, 2022},
      abstract     = {Radiotherapy can be used to treat cancer. The aim is to
                      utilize the therapeutic window to killcancer cells
                      efficiently while sparing surrounding healthy tissue as much
                      as possible. Oneapproach that already reduces complications
                      in vivo is the so-called minibeam radiotherapy.The spatially
                      alternating dose maxima and minima are designed to allow
                      significantly moreeffective tumor control compared to
                      conventional broad dose distribution. This thesis comprisesa
                      collimator study which investigated various collimator
                      models and settings to generate x-rayminibeams of best
                      possible quality. Diverse investigations and adjustments
                      made it possible todevelop an optimal setup. With the help
                      of appropriate dosimetric preparations, two largerin vitro
                      studies with H460 lung cancer cells were conducted. A volume
                      study investigatedwhether cells which received the same dose
                      are damaged differently depending on the amountof medium or
                      DPBS volumes they are covered in. The dose study, on the
                      other hand, aimedto investigate the difference between
                      conventional and minibeam irradiation. A variety
                      ofexperiments have been carried out for both studies. One
                      experiment showed the differencebetween homogeneous and
                      minibeam irradiation},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)2},
      url          = {https://inrepo02.dkfz.de/record/182522},
}