Journal Article

DKFZ-2022-02815

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1.

Delage, L. ; Lambert, M. ; Bardel, E. ; Kundlacz, C. ; Chartoire, D. ; Conchon, A. ; Peugnet, A.-L. ; Gorka, L. ; Auberger, P. ; Jacquel, A. ; Soussain, C. ; Destaing, O. ; Delecluse, H.-J.DKFZ* ; Delecluse, S.DKFZ* ; Merabet, S. ; Traverse-Glehen, A. ; Salles, G. A. ; Bachy, E. ; Billaud, M. ; Ghesquieres, H. ; Genestier, L. ; Rouault, J. P. ; Sujobert, P.

2023
American Society of Hematology Washington, DC

This record in other databases:  

Please use a persistent id in citations: doi:10.1182/blood.2022016943

Abstract: Understanding the functional role of mutated genes in cancer is required to translate the findings of cancer genomics into therapeutic improvement. BTG1 is recurrently mutated in the MCD/C5 subtype of diffuse large B cell lymphoma (DLBCL), which is associated with extranodal dissemination. There, we provide evidence that Btg1 knock-out accelerates the development of a lethal lymphoproliferative disease driven by Bcl2 overexpression. We further show that the scaffolding protein BCAR1 is a BTG1 partner. Furthermore, following BTG1 deletion or expression of BTG1 mutations observed in DLBCL patients, the overactivation of the BCAR1-RAC1 pathway confers increased migration ability in vitro and in vivo. These modifications are targetable with the SRC inhibitor dasatinib, which opens novel therapeutic opportunities in BTG1 mutated DLBCL.

Note: 2023 Mar 9;141(10):1209-1220

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Contributing Institute(s):

1. F100 Pathologie infektionsbedingter Tumoren (F100)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 20 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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