% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Langnau:182657,
      author       = {C. Langnau and H. Janing and H. Kocaman and S. Gekeler and
                      M. Günter$^*$ and Á. Petersen and P. Jaeger and B. Koch
                      and K.-P. Kreisselmeier and T. Castor and D. Rath and M.
                      Gawaz and S. E. Autenrieth$^*$ and K. Mueller},
      title        = {{R}ecovery of systemic hyperinflammation in patients with
                      severe {SARS}-{C}o{V}-2 infection.},
      journal      = {Biomarkers},
      volume       = {28},
      number       = {1},
      issn         = {1354-750X},
      address      = {London},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {DKFZ-2022-02829},
      pages        = {97-110},
      year         = {2023},
      note         = {2023 Feb;28(1):97-110},
      abstract     = {Introduction: Patients with cardiovascular disease (CVD)
                      and acute SARS-CoV-2 infection might show an altered immune
                      response during COVID-19. Material and methods: 23 patients
                      with CVD and SARS-CoV-2 infection were prospectively
                      enrolled and received a cardiological assessment at study
                      entry and during follow-up visit. Inclusion criteria of our
                      study were age older than 18 years, presence of CVD, and
                      acute SARS-CoV-2 infection. The median age of the patient
                      cohort was 69 (IQR 55-79) years. 12 $(52.2\%)$ patients were
                      men. Peripheral monocytes and chemokine/cytokine profiles
                      were analyzed. Results: Numbers of classical and
                      non-classical monocytes were significantly decreased during
                      acute SARS-CoV-2 infection compared to 3-month recovery.
                      While classical monocytes reached the expected level in
                      peripheral blood after 3 months, the number of non-classical
                      monocytes remained significantly reduced. Discussion: All
                      three monocyte subsets exhibited changes of established
                      adhesion and activation markers. Interestingly, they also
                      expressed higher levels of pro-inflammatory cytokines like
                      macrophage migration inhibitory factor (MIF) at the time of
                      recovery, although MIF was only slightly increased during
                      the acute phase. Conclusion: Changes of monocyte phenotypes
                      and increased MIF expression after 3-month recovery from
                      acute SARS-CoV-2 infection may indicate persistent, possibly
                      long-lasting, pro-inflammatory monocyte function in CVD
                      patients.},
      keywords     = {SARS-CoV-2 infection (Other) / hyperinflammation (Other) /
                      monocytes (Other) / platelets (Other) / recovery (Other)},
      cin          = {F171},
      ddc          = {610},
      cid          = {I:(DE-He78)F171-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36377411},
      doi          = {10.1080/1354750X.2022.2148745},
      url          = {https://inrepo02.dkfz.de/record/182657},
}