Journal Article

DKFZ-2022-02829

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Recovery of systemic hyperinflammation in patients with severe SARS-CoV-2 infection.

Langnau, C. ; Janing, H. ; Kocaman, H. ; Gekeler, S. ; Günter, M.DKFZ* ; Petersen, Á. ; Jaeger, P. ; Koch, B. ; Kreisselmeier, K.-P. ; Castor, T. ; Rath, D. ; Gawaz, M. ; Autenrieth, S. E.DKFZ* ; Mueller, K.

2023
Taylor & Francis London

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Please use a persistent id in citations: doi:10.1080/1354750X.2022.2148745

Abstract: Introduction: Patients with cardiovascular disease (CVD) and acute SARS-CoV-2 infection might show an altered immune response during COVID-19. Material and methods: 23 patients with CVD and SARS-CoV-2 infection were prospectively enrolled and received a cardiological assessment at study entry and during follow-up visit. Inclusion criteria of our study were age older than 18 years, presence of CVD, and acute SARS-CoV-2 infection. The median age of the patient cohort was 69 (IQR 55-79) years. 12 (52.2%) patients were men. Peripheral monocytes and chemokine/cytokine profiles were analyzed. Results: Numbers of classical and non-classical monocytes were significantly decreased during acute SARS-CoV-2 infection compared to 3-month recovery. While classical monocytes reached the expected level in peripheral blood after 3 months, the number of non-classical monocytes remained significantly reduced. Discussion: All three monocyte subsets exhibited changes of established adhesion and activation markers. Interestingly, they also expressed higher levels of pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF) at the time of recovery, although MIF was only slightly increased during the acute phase. Conclusion: Changes of monocyte phenotypes and increased MIF expression after 3-month recovery from acute SARS-CoV-2 infection may indicate persistent, possibly long-lasting, pro-inflammatory monocyte function in CVD patients.

Keyword(s): SARS-CoV-2 infection ; hyperinflammation ; monocytes ; platelets ; recovery

Note: 2023 Feb;28(1):97-110

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Contributing Institute(s):

1. Dentritische Zellen bei Infektionen und Krebs (F171)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2022

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