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001     182657
005     20240229145726.0
024 7 _ |a 10.1080/1354750X.2022.2148745
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024 7 _ |a pmid:36377411
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024 7 _ |a 1354-750X
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024 7 _ |a 1366-5804
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037 _ _ |a DKFZ-2022-02829
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Langnau, Carolin
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245 _ _ |a Recovery of systemic hyperinflammation in patients with severe SARS-CoV-2 infection.
260 _ _ |a London
|c 2023
|b Taylor & Francis
336 7 _ |a article
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336 7 _ |a Journal Article
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500 _ _ |a 2023 Feb;28(1):97-110
520 _ _ |a Introduction: Patients with cardiovascular disease (CVD) and acute SARS-CoV-2 infection might show an altered immune response during COVID-19. Material and methods: 23 patients with CVD and SARS-CoV-2 infection were prospectively enrolled and received a cardiological assessment at study entry and during follow-up visit. Inclusion criteria of our study were age older than 18 years, presence of CVD, and acute SARS-CoV-2 infection. The median age of the patient cohort was 69 (IQR 55-79) years. 12 (52.2%) patients were men. Peripheral monocytes and chemokine/cytokine profiles were analyzed. Results: Numbers of classical and non-classical monocytes were significantly decreased during acute SARS-CoV-2 infection compared to 3-month recovery. While classical monocytes reached the expected level in peripheral blood after 3 months, the number of non-classical monocytes remained significantly reduced. Discussion: All three monocyte subsets exhibited changes of established adhesion and activation markers. Interestingly, they also expressed higher levels of pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF) at the time of recovery, although MIF was only slightly increased during the acute phase. Conclusion: Changes of monocyte phenotypes and increased MIF expression after 3-month recovery from acute SARS-CoV-2 infection may indicate persistent, possibly long-lasting, pro-inflammatory monocyte function in CVD patients.
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650 _ 7 |a SARS-CoV-2 infection
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650 _ 7 |a hyperinflammation
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650 _ 7 |a monocytes
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650 _ 7 |a platelets
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650 _ 7 |a recovery
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700 1 _ |a Janing, Henrik
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700 1 _ |a Kocaman, Hüseyin
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700 1 _ |a Gekeler, Sarah
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700 1 _ |a Günter, Manina
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700 1 _ |a Petersen, Álvaro
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700 1 _ |a Jaeger, Philippa
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700 1 _ |a Koch, Barbara
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700 1 _ |a Kreisselmeier, Klaus-Peter
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700 1 _ |a Castor, Tatsiana
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700 1 _ |a Rath, Dominik
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700 1 _ |a Gawaz, Meinrad
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700 1 _ |a Autenrieth, Stella E
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700 1 _ |a Mueller, Karin
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