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@ARTICLE{Pham:182798,
      author       = {T.-T. Pham and K. Nimptsch and K. Aleksandrova and M. Jenab
                      and R. Reichmann and K. Wu and A. Tjønneland and C. Kyrø
                      and M. B. Schulze and R. Kaaks$^*$ and V. Katzke$^*$ and D.
                      Palli and F. Pasanisi and F. Ricceri and R. Tumino and V.
                      Krogh and J. Roodhart and J. Castilla and M.-J. Sánchez and
                      S. M. Colorado-Yohar and J. Harbs and M. Rutegård and K.
                      Papier and E. K. Aglago and N. Dimou and A.-L. Mayen-Chacon
                      and E. Weiderpass and T. Pischon},
      title        = {{P}re-{D}iagnostic {C}irculating {R}esistin
                      {C}oncentrations {A}re {N}ot {A}ssociated with {C}olorectal
                      {C}ancer {R}isk in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition {S}tudy.},
      journal      = {Cancers},
      volume       = {14},
      number       = {22},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-02930},
      pages        = {5499},
      year         = {2022},
      abstract     = {Resistin is a polypeptide implicated in inflammatory
                      processes, and as such could be linked to colorectal
                      carcinogenesis. In case-control studies, higher resistin
                      levels have been found in colorectal cancer (CRC) patients
                      compared to healthy individuals. However, evidence for the
                      association between pre-diagnostic resistin and CRC risk is
                      scarce. We investigated pre-diagnostic resistin
                      concentrations and CRC risk within the European Prospective
                      Investigation into Cancer and Nutrition using a nested
                      case-control study among 1293 incident CRC-diagnosed cases
                      and 1293 incidence density-matched controls. Conditional
                      logistic regression models controlled for matching factors
                      (age, sex, study center, fasting status, and women-related
                      factors in women) and potential confounders (education,
                      dietary and lifestyle factors, body mass index (BMI),
                      BMI-adjusted waist circumference residuals) were used to
                      estimate relative risks (RRs) and $95\%$ confidence
                      intervals (CIs) for CRC. Higher circulating resistin
                      concentrations were not associated with CRC (RR per doubling
                      resistin, 1.11; $95\%$ CI 0.94-1.30; p = 0.22). There were
                      also no associations with CRC subgroups defined by tumor
                      subsite or sex. However, resistin was marginally associated
                      with a higher CRC risk among participants followed-up
                      maximally two years, but not among those followed-up after
                      more than two years. We observed no substantial correlation
                      between baseline circulating resistin concentrations and
                      adiposity measures (BMI, waist circumference), adipokines
                      (adiponectin, leptin), or metabolic and inflammatory
                      biomarkers (C-reactive protein, C-peptide, high-density
                      lipoprotein cholesterol, reactive oxygen metabolites) among
                      controls. In this large-scale prospective cohort, there was
                      little evidence of an association between baseline
                      circulating resistin concentrations and CRC risk in European
                      men and women.},
      keywords     = {colorectal cancer (Other) / inflammation (Other) /
                      pre-diagnostic resistin (Other) / prospective (Other) / risk
                      (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36428592},
      doi          = {10.3390/cancers14225499},
      url          = {https://inrepo02.dkfz.de/record/182798},
}