Journal Article

DKFZ-2022-02930

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study.

Pham, T.-T. ; Nimptsch, K. ; Aleksandrova, K. ; Jenab, M. ; Reichmann, R. ; Wu, K. ; Tjønneland, A. ; Kyrø, C. ; Schulze, M. B. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Palli, D. ; Pasanisi, F. ; Ricceri, F. ; Tumino, R. ; Krogh, V. ; Roodhart, J. ; Castilla, J. ; Sánchez, M.-J. ; Colorado-Yohar, S. M. ; Harbs, J. ; Rutegård, M. ; Papier, K. ; Aglago, E. K. ; Dimou, N. ; Mayen-Chacon, A.-L. ; Weiderpass, E. ; Pischon, T.

2022
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers14225499

Abstract: Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94-1.30; p = 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women.

Keyword(s): colorectal cancer ; inflammation ; pre-diagnostic resistin ; prospective ; risk

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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