TY  - JOUR
AU  - Nikitina, Ekaterina
AU  - Alikhanyan, Kristina
AU  - Nessling, Michelle
AU  - Richter, Karsten
AU  - Kaden, Sylvia
AU  - Ernst, Claudia
AU  - Seitz, Stefan
AU  - Chuprikova, Liubov
AU  - Häfele, Lisa
AU  - Gunst, Karin
AU  - Rahbari, Nuh
AU  - Birgin, Emrullah
AU  - Rasbach, Erik
AU  - Rahbari, Mohammad
AU  - Brobeil, Alexander
AU  - Schenk, Miriam
AU  - Büchler, Markus
AU  - de Villiers, Ethel-Michele
AU  - Bund, Timo
AU  - zur Hausen, Harald
TI  - Structural Expression of BMMF in tissues of colorectal, lung and pancreatic cancer patients.
JO  - International journal of cancer
VL  - 153
IS  - 1
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2022-02949
SP  - 173-182
PY  - 2023
N1  - #EA:F200#EA:W230#LA:F200# / 2023 Jul 1;153(1):173-182
AB  - Chronic inflammation, linked to the presence of bovine milk and meat factors (BMMF) and specific subsets of macrophages, results in oxygen radical synthesis and induction of mutations in DNA of actively replicating cells and replicating single stranded DNA (zur Hausen et al., 2017). Cancers arising from this process have been characterized as indirect carcinogenesis by infectious agents (without persistence of genes of the agent in premalignant or cancers cells). Here we investigate structural properties of pleomorphic vesicles, regularly identified by staining peritumour tissues of colorectal, lung and pancreatic cancer for expression of BMMF Rep. The latter represents a subgroup of BMMF1 proteins involved in replication of small single-stranded circular plasmids of BMMF, but most likely also contributing to pleomorphic vesicular structures found in the periphery of colorectal, lung and pancreatic cancers. Structurally dense regions are demonstrated in preselected areas of colorectal cancer, after staining with monoclonal antibodies against BMMF1 Rep. Similar structures were observed in human embryonic cells (HEK293TT) overexpressing Rep. These data suggest that Rep or Rep isoforms contribute to the structural formation of vesicles. This article is protected by copyright. All rights reserved.
KW  - BMMF (Other)
KW  - electron microscopy (Other)
KW  - indirect infectious carcinogenesis (Other)
KW  - vesicular structure of BMMF (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36444499
DO  - DOI:10.1002/ijc.34374
UR  - https://inrepo02.dkfz.de/record/182817
ER  -