Journal Article

DKFZ-2022-02949

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Structural Expression of BMMF in tissues of colorectal, lung and pancreatic cancer patients.

Nikitina, E. (First author)DKFZ* ; Alikhanyan, K. (First author)DKFZ* ; Nessling, M. (First author)DKFZ* ; Richter, K. (First author)DKFZ* ; Kaden, S.DKFZ* ; Ernst, C.DKFZ* ; Seitz, S.DKFZ* ; Chuprikova, L.DKFZ* ; Häfele, L.DKFZ* ; Gunst, K.DKFZ* ; Rahbari, N. ; Birgin, E. ; Rasbach, E. ; Rahbari, M.DKFZ* ; Brobeil, A. ; Schenk, M. ; Büchler, M. ; de Villiers, E.-M.DKFZ* ; Bund, T.DKFZ* ; zur Hausen, H. (Last author)DKFZ*

2023
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.34374

Abstract: Chronic inflammation, linked to the presence of bovine milk and meat factors (BMMF) and specific subsets of macrophages, results in oxygen radical synthesis and induction of mutations in DNA of actively replicating cells and replicating single stranded DNA (zur Hausen et al., 2017). Cancers arising from this process have been characterized as indirect carcinogenesis by infectious agents (without persistence of genes of the agent in premalignant or cancers cells). Here we investigate structural properties of pleomorphic vesicles, regularly identified by staining peritumour tissues of colorectal, lung and pancreatic cancer for expression of BMMF Rep. The latter represents a subgroup of BMMF1 proteins involved in replication of small single-stranded circular plasmids of BMMF, but most likely also contributing to pleomorphic vesicular structures found in the periphery of colorectal, lung and pancreatic cancers. Structurally dense regions are demonstrated in preselected areas of colorectal cancer, after staining with monoclonal antibodies against BMMF1 Rep. Similar structures were observed in human embryonic cells (HEK293TT) overexpressing Rep. These data suggest that Rep or Rep isoforms contribute to the structural formation of vesicles. This article is protected by copyright. All rights reserved.

Keyword(s): BMMF ; electron microscopy ; indirect infectious carcinogenesis ; vesicular structure of BMMF

Note: #EA:F200#EA:W230#LA:F200# / 2023 Jul 1;153(1):173-182

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Contributing Institute(s):

1. F200 AG Episomal-Persistierende DNA in Krebs- und chron. Erkrankungen (F200)
2. Elektronenmikroskopie (W230)
3. F170 Virus-assoziierte Karzinogenese (F170)
4. F180 Chronische Entzündung und Krebs (F180)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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