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@ARTICLE{Nikitina:182817,
      author       = {E. Nikitina$^*$ and K. Alikhanyan$^*$ and M. Nessling$^*$
                      and K. Richter$^*$ and S. Kaden$^*$ and C. Ernst$^*$ and S.
                      Seitz$^*$ and L. Chuprikova$^*$ and L. Häfele$^*$ and K.
                      Gunst$^*$ and N. Rahbari and E. Birgin and E. Rasbach and M.
                      Rahbari$^*$ and A. Brobeil and M. Schenk and M. Büchler and
                      E.-M. de Villiers$^*$ and T. Bund$^*$ and H. zur Hausen$^*$},
      title        = {{S}tructural {E}xpression of {BMMF} in tissues of
                      colorectal, lung and pancreatic cancer patients.},
      journal      = {International journal of cancer},
      volume       = {153},
      number       = {1},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2022-02949},
      pages        = {173-182},
      year         = {2023},
      note         = {#EA:F200#EA:W230#LA:F200# / 2023 Jul 1;153(1):173-182},
      abstract     = {Chronic inflammation, linked to the presence of bovine milk
                      and meat factors (BMMF) and specific subsets of macrophages,
                      results in oxygen radical synthesis and induction of
                      mutations in DNA of actively replicating cells and
                      replicating single stranded DNA (zur Hausen et al., 2017).
                      Cancers arising from this process have been characterized as
                      indirect carcinogenesis by infectious agents (without
                      persistence of genes of the agent in premalignant or cancers
                      cells). Here we investigate structural properties of
                      pleomorphic vesicles, regularly identified by staining
                      peritumour tissues of colorectal, lung and pancreatic cancer
                      for expression of BMMF Rep. The latter represents a subgroup
                      of BMMF1 proteins involved in replication of small
                      single-stranded circular plasmids of BMMF, but most likely
                      also contributing to pleomorphic vesicular structures found
                      in the periphery of colorectal, lung and pancreatic cancers.
                      Structurally dense regions are demonstrated in preselected
                      areas of colorectal cancer, after staining with monoclonal
                      antibodies against BMMF1 Rep. Similar structures were
                      observed in human embryonic cells (HEK293TT) overexpressing
                      Rep. These data suggest that Rep or Rep isoforms contribute
                      to the structural formation of vesicles. This article is
                      protected by copyright. All rights reserved.},
      keywords     = {BMMF (Other) / electron microscopy (Other) / indirect
                      infectious carcinogenesis (Other) / vesicular structure of
                      BMMF (Other)},
      cin          = {F200 / W230 / F170 / F180},
      ddc          = {610},
      cid          = {I:(DE-He78)F200-20160331 / I:(DE-He78)W230-20160331 /
                      I:(DE-He78)F170-20160331 / I:(DE-He78)F180-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36444499},
      doi          = {10.1002/ijc.34374},
      url          = {https://inrepo02.dkfz.de/record/182817},
}