%0 Journal Article
%A Joshi, Smita
%A Anantharaman, Devasena
%A Muwonge, Richard
%A Bhatla, Neerja
%A Panicker, Gitika
%A Butt, Julia Anna
%A Rani Reddy Poli, Usha
%A Malvi, Sylla G
%A Esmy, Pulikkottil O
%A Lucas, Eric
%A Verma, Yogesh
%A Shah, Anand
%A Zomawia, Eric
%A Pimple, Sharmila
%A Jayant, Kasturi
%A Hingmire, Sanjay
%A Chiwate, Aruna
%A Divate, Uma
%A Vashist, Shachi
%A Mishra, Gauravi
%A Jadhav, Radhika
%A Siddiqi, Maqsood
%A Sankaran, Subha
%A Pillai Rameshwari Ammal Kannan, Thiraviam
%A Kartha, Purnima
%A Shastri, Surendra S
%A Sauvaget, Catherine
%A Radhakrishna Pillai, M.
%A Waterboer, Tim
%A Müller, Martin
%A Sehr, Peter
%A Unger, Elizabeth R
%A Sankaranarayanan, Rengaswamy
%A Basu, Partha
%T Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination.
%J Vaccine
%V 1
%N 4
%@ 0264-410X
%C Amsterdam
%I Elsevier
%M DKFZ-2022-02961
%P 236-245
%D 2023
%Z Volume 41, Issue 1, 4 January 2023, Pages 236-245
%X The recent World Health Organization recommendation supporting single-dose of HPV vaccine will significantly reduce programmatic cost, mitigate the supply shortage, and simplify logistics, thus allowing more low- and middle-income countries to introduce the vaccine. From a programmatic perspective the durability of protection offered by a single-dose will be a key consideration. The primary objectives of the present study were to determine whether recipients of a single-dose of quadrivalent HPV vaccine had sustained immune response against targeted HPV types (HPV 6,11,16,18) at 10 years post-vaccination and whether this response was superior to the natural antibody titres observed in unvaccinated women.Participants received at age 10-18 years either one, two or three doses of the quadrivalent HPV vaccine. Serology samples were obtained at different timepoints up to 10 years after vaccination from a convenience sample of vaccinated participants and from age-matched unvaccinated women at one timepoint. The evolution of the binding and neutralizing antibody response was presented by dose received. 10-year durability of immune responses induced by a single-dose was compared to that after three doses of the vaccine and in unvaccinated married women.The dynamics of antibody response among the single-dose recipients observed over 120 months show stabilized levels 18 months after vaccination for all four HPV types. Although the HPV type-specific (binding or neutralizing) antibody titres after a single-dose were significantly inferior to those after three doses of the vaccine (lower bounds of GMT ratios < 0.5), they were all significantly higher than those observed in unvaccinated women following natural infections (GMT ratios: 2.05 to 4.04-fold higher). The results correlate well with the high vaccine efficacy of single-dose against persistent HPV 16/18 infections reported by us earlier at 10-years post-vaccination.Our study demonstrates the high and durable immune response in single-dose recipients of HPV vaccine at 10-years post vaccination.
%K Human papillomavirus (Other)
%K Natural immunity (Other)
%K Single dose (Other)
%K Vaccine immune responses (Other)
%K quadrivalent HPV vaccine (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36446654
%R 10.1016/j.vaccine.2022.11.044
%U https://inrepo02.dkfz.de/record/182834