Journal Article

DKFZ-2022-02961

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination.

Joshi, S. ; Anantharaman, D. ; Muwonge, R. ; Bhatla, N. ; Panicker, G. ; Butt, J. A.DKFZ* ; Rani Reddy Poli, U. ; Malvi, S. G. ; Esmy, P. O. ; Lucas, E. ; Verma, Y. ; Shah, A. ; Zomawia, E. ; Pimple, S. ; Jayant, K. ; Hingmire, S. ; Chiwate, A. ; Divate, U. ; Vashist, S. ; Mishra, G. ; Jadhav, R. ; Siddiqi, M. ; Sankaran, S. ; Pillai Rameshwari Ammal Kannan, T. ; Kartha, P. ; Shastri, S. S. ; Sauvaget, C. ; Radhakrishna Pillai, M. ; Waterboer, T.DKFZ* ; Müller, M.DKFZ* ; Sehr, P.DKFZ* ; Unger, E. R. ; Sankaranarayanan, R. ; Basu, P.

2023
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.vaccine.2022.11.044

Abstract: The recent World Health Organization recommendation supporting single-dose of HPV vaccine will significantly reduce programmatic cost, mitigate the supply shortage, and simplify logistics, thus allowing more low- and middle-income countries to introduce the vaccine. From a programmatic perspective the durability of protection offered by a single-dose will be a key consideration. The primary objectives of the present study were to determine whether recipients of a single-dose of quadrivalent HPV vaccine had sustained immune response against targeted HPV types (HPV 6,11,16,18) at 10 years post-vaccination and whether this response was superior to the natural antibody titres observed in unvaccinated women.Participants received at age 10-18 years either one, two or three doses of the quadrivalent HPV vaccine. Serology samples were obtained at different timepoints up to 10 years after vaccination from a convenience sample of vaccinated participants and from age-matched unvaccinated women at one timepoint. The evolution of the binding and neutralizing antibody response was presented by dose received. 10-year durability of immune responses induced by a single-dose was compared to that after three doses of the vaccine and in unvaccinated married women.The dynamics of antibody response among the single-dose recipients observed over 120 months show stabilized levels 18 months after vaccination for all four HPV types. Although the HPV type-specific (binding or neutralizing) antibody titres after a single-dose were significantly inferior to those after three doses of the vaccine (lower bounds of GMT ratios < 0.5), they were all significantly higher than those observed in unvaccinated women following natural infections (GMT ratios: 2.05 to 4.04-fold higher). The results correlate well with the high vaccine efficacy of single-dose against persistent HPV 16/18 infections reported by us earlier at 10-years post-vaccination.Our study demonstrates the high and durable immune response in single-dose recipients of HPV vaccine at 10-years post vaccination.

Keyword(s): Human papillomavirus ; Natural immunity ; Single dose ; Vaccine immune responses ; quadrivalent HPV vaccine

Note: Volume 41, Issue 1, 4 January 2023, Pages 236-245

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Contributing Institute(s):

1. Infektionen und Krebs-Epidemiologie (F020)
2. Gruppe Sehr EMBL (W040)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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