TY  - JOUR
AU  - Joshi, Smita
AU  - Anantharaman, Devasena
AU  - Muwonge, Richard
AU  - Bhatla, Neerja
AU  - Panicker, Gitika
AU  - Butt, Julia Anna
AU  - Rani Reddy Poli, Usha
AU  - Malvi, Sylla G
AU  - Esmy, Pulikkottil O
AU  - Lucas, Eric
AU  - Verma, Yogesh
AU  - Shah, Anand
AU  - Zomawia, Eric
AU  - Pimple, Sharmila
AU  - Jayant, Kasturi
AU  - Hingmire, Sanjay
AU  - Chiwate, Aruna
AU  - Divate, Uma
AU  - Vashist, Shachi
AU  - Mishra, Gauravi
AU  - Jadhav, Radhika
AU  - Siddiqi, Maqsood
AU  - Sankaran, Subha
AU  - Pillai Rameshwari Ammal Kannan, Thiraviam
AU  - Kartha, Purnima
AU  - Shastri, Surendra S
AU  - Sauvaget, Catherine
AU  - Radhakrishna Pillai, M.
AU  - Waterboer, Tim
AU  - Müller, Martin
AU  - Sehr, Peter
AU  - Unger, Elizabeth R
AU  - Sankaranarayanan, Rengaswamy
AU  - Basu, Partha
TI  - Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination.
JO  - Vaccine
VL  - 1
IS  - 4
SN  - 0264-410X
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2022-02961
SP  - 236-245
PY  - 2023
N1  - Volume 41, Issue 1, 4 January 2023, Pages 236-245
AB  - The recent World Health Organization recommendation supporting single-dose of HPV vaccine will significantly reduce programmatic cost, mitigate the supply shortage, and simplify logistics, thus allowing more low- and middle-income countries to introduce the vaccine. From a programmatic perspective the durability of protection offered by a single-dose will be a key consideration. The primary objectives of the present study were to determine whether recipients of a single-dose of quadrivalent HPV vaccine had sustained immune response against targeted HPV types (HPV 6,11,16,18) at 10 years post-vaccination and whether this response was superior to the natural antibody titres observed in unvaccinated women.Participants received at age 10-18 years either one, two or three doses of the quadrivalent HPV vaccine. Serology samples were obtained at different timepoints up to 10 years after vaccination from a convenience sample of vaccinated participants and from age-matched unvaccinated women at one timepoint. The evolution of the binding and neutralizing antibody response was presented by dose received. 10-year durability of immune responses induced by a single-dose was compared to that after three doses of the vaccine and in unvaccinated married women.The dynamics of antibody response among the single-dose recipients observed over 120 months show stabilized levels 18 months after vaccination for all four HPV types. Although the HPV type-specific (binding or neutralizing) antibody titres after a single-dose were significantly inferior to those after three doses of the vaccine (lower bounds of GMT ratios < 0.5), they were all significantly higher than those observed in unvaccinated women following natural infections (GMT ratios: 2.05 to 4.04-fold higher). The results correlate well with the high vaccine efficacy of single-dose against persistent HPV 16/18 infections reported by us earlier at 10-years post-vaccination.Our study demonstrates the high and durable immune response in single-dose recipients of HPV vaccine at 10-years post vaccination.
KW  - Human papillomavirus (Other)
KW  - Natural immunity (Other)
KW  - Single dose (Other)
KW  - Vaccine immune responses (Other)
KW  - quadrivalent HPV vaccine (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36446654
DO  - DOI:10.1016/j.vaccine.2022.11.044
UR  - https://inrepo02.dkfz.de/record/182834
ER  -