TY  - JOUR
AU  - Chen, Xuechen
AU  - Ding, Jie
AU  - Li, Hengjing
AU  - Carr, Prudence R
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - The power of a healthy lifestyle for cancer prevention: the example of colorectal cancer.
JO  - Cancer biology & medicine
VL  - 19
IS  - 11
SN  - 2095-3941
CY  - Tianjin
PB  - Medical Univ. Cancer Inst. & Hospital
M1  - DKFZ-2022-03016
SP  - 1586 - 1597
PY  - 2022
N1  - #EA:C070#LA:C070#LA:C120#
AB  - We aimed to directly compare the estimated effects of adherence to a healthy lifestyle with those of risk predisposition according to known genetic variants affecting colorectal cancer (CRC) risk, to support effective risk communication for cancer prevention.A healthy lifestyle score (HLS) was derived from 5 lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body adiposity. The association of lifestyle and polygenic risk score (PRS) (based on 140 CRC-associated risk loci) with CRC risk was assessed with multiple logistic regression and compared through the genetic risk equivalent (GRE), a novel approach providing an estimate of the effects of adherence to a healthy lifestyle in terms of percentile differences in PRS.A higher HLS was associated with lower CRC risk (4,844 cases, 3,964 controls). Those adhering to all 5 healthy lifestyle factors had a 62
KW  - Colorectal cancer (Other)
KW  - family history (Other)
KW  - genetic risk equivalent (Other)
KW  - healthy lifestyle score (Other)
KW  - polygenic risk score (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36476570
DO  - DOI:10.20892/j.issn.2095-3941.2022.0397
UR  - https://inrepo02.dkfz.de/record/186219
ER  -