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000186245 1001_ $$aAli, Esraa$$b0
000186245 245__ $$aActivated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies.
000186245 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
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000186245 520__ $$aHepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. aHSCs suppress the anti-tumor immune response through interaction with different immune cells. They also increase the deposition of the extracellular matrix proteins, challenging the reversion of fibrosis and increasing HCC growth and metastasis. Therapy for HCC was reported to activate HSCs, which could explain the low efficacy of current treatments. Conversely, recent studies aimed at the deactivation of HSCs show that they have been able to inhibit HCC growth. In this review article, we discuss the role of aHSCs in HCC pathophysiology and therapy. Finally, we provide suggestions for the experimental implementation of HSCs in HCC therapies.
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000186245 650_7 $$2Other$$afibrosis regression
000186245 650_7 $$2Other$$ahepatic stellate cells
000186245 650_7 $$2Other$$ahepatocellular carcinoma
000186245 650_7 $$2Other$$atherapeutic studies
000186245 7001_ $$00000-0001-8888-0759$$aTrailin, Andriy$$b1
000186245 7001_ $$00000-0001-6850-780X$$aAmbrozkiewicz, Filip$$b2
000186245 7001_ $$aLiška, Václav$$b3
000186245 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b4$$eLast author$$udkfz
000186245 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms232315292$$gVol. 23, no. 23, p. 15292 -$$n23$$p15292$$tInternational journal of molecular sciences$$v23$$x1422-0067$$y2022
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