Journal Article (Review Article)

DKFZ-2022-03039

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies.

Ali, E. ; Trailin, A. ; Ambrozkiewicz, F. ; Liška, V. ; Hemminki, K. (Last author)DKFZ*

2022
Molecular Diversity Preservation International Basel

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Please use a persistent id in citations: doi:10.3390/ijms232315292

Abstract: Hepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. aHSCs suppress the anti-tumor immune response through interaction with different immune cells. They also increase the deposition of the extracellular matrix proteins, challenging the reversion of fibrosis and increasing HCC growth and metastasis. Therapy for HCC was reported to activate HSCs, which could explain the low efficacy of current treatments. Conversely, recent studies aimed at the deactivation of HSCs show that they have been able to inhibit HCC growth. In this review article, we discuss the role of aHSCs in HCC pathophysiology and therapy. Finally, we provide suggestions for the experimental implementation of HSCs in HCC therapies.

Keyword(s): fibrosis regression ; hepatic stellate cells ; hepatocellular carcinoma ; therapeutic studies

Note: #LA:C020#

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
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