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001     186452
005     20240229145746.0
024 7 _ |a 10.1016/j.neuron.2022.12.005
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024 7 _ |a pmid:36549270
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024 7 _ |a 0896-6273
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024 7 _ |a 1097-4199
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037 _ _ |a DKFZ-2022-03173
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Vieira, José Ricardo
|b 0
245 _ _ |a Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.
260 _ _ |a New York, NY
|c 2022
|b Elsevier
336 7 _ |a article
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520 _ _ |a How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and endothelial cells (ECs), necessary for the coordinated development of MNs. By analyzing cell-to-cell interaction profiles of the mouse developing spinal cord, we uncovered semaphorin 3C (Sema3C) and PlexinD1 as a communication axis between MNs and ECs. Using cell-specific knockout mice and in vitro assays, we demonstrate that removal of Sema3C in MNs, or its receptor PlexinD1 in ECs, results in premature and aberrant vascularization of MN columns. Those vascular defects impair MN axon exit from the spinal cord. Impaired PlexinD1 signaling in ECs also causes MN maturation defects at later stages. This study highlights the importance of a timely and spatially controlled communication between MNs and ECs for proper spinal cord development.
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650 _ 7 |a CNS vascularization
|2 Other
650 _ 7 |a PlexinD1
|2 Other
650 _ 7 |a Sema3C
|2 Other
650 _ 7 |a blood vessel
|2 Other
650 _ 7 |a endothelial cell
|2 Other
650 _ 7 |a motor neuron
|2 Other
650 _ 7 |a neuro-vascular communication
|2 Other
650 _ 7 |a neurodevelopment
|2 Other
650 _ 7 |a spinal cord
|2 Other
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Endothelial Cells
|2 MeSH
650 _ 2 |a Motor Neurons: physiology
|2 MeSH
650 _ 2 |a Spinal Cord
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
650 _ 2 |a Axons
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
700 1 _ |a Shah, Bhavin
|b 1
700 1 _ |a Dupraz, Sebastian
|b 2
700 1 _ |a Paredes, Isidora
|b 3
700 1 _ |a Himmels, Patricia
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700 1 _ |a Schermann, Géza
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700 1 _ |a Adler, Heike
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700 1 _ |a Motta, Alessia
|b 7
700 1 _ |a Gärtner, Lea
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700 1 _ |a Navarro-Aragall, Ariadna
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700 1 _ |a Ioannou, Elena
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700 1 _ |a Dyukova, Elena
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700 1 _ |a Bonnavion, Remy
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700 1 _ |a Fischer, Andreas
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700 1 _ |a Bonanomi, Dario
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700 1 _ |a Bradke, Frank
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700 1 _ |a Ruhrberg, Christiana
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700 1 _ |a Ruiz de Almodóvar, Carmen
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773 _ _ |a 10.1016/j.neuron.2022.12.005
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