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@ARTICLE{GilLespinard:186465,
      author       = {M. Gil-Lespinard and J. Castañeda and E. Almanza-Aguilera
                      and J. H. Gómez and A. Tjønneland and C. Kyrø and K.
                      Overvad and V. Katzke$^*$ and M. B. Schulze and G. Masala
                      and C. Agnoli and M. Santucci de Magistris and R. Tumino and
                      C. Sacerdote and G. Skeie and C. Lasheras and E.
                      Molina-Montes and J. M. Huerta and A. Barricarte and P.
                      Amiano and E. Sonestedt and M. da Silva and I. Johansson and
                      J. Hultdin and A. M. May and N. G. Forouhi and A. K. Heath
                      and H. Freisling and E. Weiderpass and A. Scalbert and R.
                      Zamora-Ros},
      title        = {{D}ietary {I}ntake of 91 {I}ndividual {P}olyphenols and
                      5-{Y}ear {B}ody {W}eight {C}hange in the {EPIC}-{PANACEA}
                      {C}ohort.},
      journal      = {Antioxidants},
      volume       = {11},
      number       = {12},
      issn         = {2076-3921},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-03186},
      pages        = {2425},
      year         = {2022},
      abstract     = {Polyphenols are bioactive compounds from plants with
                      antioxidant properties that may have a protective role
                      against body weight gain, with adipose tissue and systemic
                      oxidative stress as potential targets. We aimed to
                      investigate the dietary intake of individual polyphenols and
                      their association with 5-year body weight change in a
                      sub-cohort of the European Prospective Investigation into
                      Cancer and Nutrition (EPIC). This study included 349,165
                      adult participants from nine European countries. Polyphenol
                      intake was estimated through country-specific validated
                      dietary questionnaires and the Phenol-Explorer database.
                      Body weight was obtained at recruitment and after a mean
                      follow-up time of 5 years. Associations were estimated using
                      multilevel mixed linear regression models. From 91
                      polyphenols included, the majority (n = 67) were inversely
                      associated with 5-year body weight change after
                      FDR-correction (q < 0.05). The greatest inverse associations
                      were observed for quercetin 3-O-rhamnoside (change in weight
                      for doubling in intake: -0.071 $(95\%$ CI: -0.085; -0.056)
                      kg/5 years). Only 13 polyphenols showed positive
                      associations with body weight gain, mainly from the subclass
                      hydroxycinnamic acids (HCAs) with coffee as the main dietary
                      source, such as 4-caffeoylquinic acid (0.029 $(95\%$ CI:
                      0.021; 0.038) kg/5 years). Individual polyphenols with
                      fruit, tea, cocoa and whole grain cereals as the main
                      dietary sources may contribute to body weight maintenance in
                      adults. Individual HCAs may have different roles in body
                      weight change depending on their dietary source.},
      keywords     = {EPIC (Other) / body weight (Other) / cohort (Other) /
                      intake (Other) / obesity (Other) / polyphenol (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36552633},
      pmc          = {pmc:PMC9774775},
      doi          = {10.3390/antiox11122425},
      url          = {https://inrepo02.dkfz.de/record/186465},
}