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@ARTICLE{GilLespinard:186465,
author = {M. Gil-Lespinard and J. Castañeda and E. Almanza-Aguilera
and J. H. Gómez and A. Tjønneland and C. Kyrø and K.
Overvad and V. Katzke$^*$ and M. B. Schulze and G. Masala
and C. Agnoli and M. Santucci de Magistris and R. Tumino and
C. Sacerdote and G. Skeie and C. Lasheras and E.
Molina-Montes and J. M. Huerta and A. Barricarte and P.
Amiano and E. Sonestedt and M. da Silva and I. Johansson and
J. Hultdin and A. M. May and N. G. Forouhi and A. K. Heath
and H. Freisling and E. Weiderpass and A. Scalbert and R.
Zamora-Ros},
title = {{D}ietary {I}ntake of 91 {I}ndividual {P}olyphenols and
5-{Y}ear {B}ody {W}eight {C}hange in the {EPIC}-{PANACEA}
{C}ohort.},
journal = {Antioxidants},
volume = {11},
number = {12},
issn = {2076-3921},
address = {Basel},
publisher = {MDPI},
reportid = {DKFZ-2022-03186},
pages = {2425},
year = {2022},
abstract = {Polyphenols are bioactive compounds from plants with
antioxidant properties that may have a protective role
against body weight gain, with adipose tissue and systemic
oxidative stress as potential targets. We aimed to
investigate the dietary intake of individual polyphenols and
their association with 5-year body weight change in a
sub-cohort of the European Prospective Investigation into
Cancer and Nutrition (EPIC). This study included 349,165
adult participants from nine European countries. Polyphenol
intake was estimated through country-specific validated
dietary questionnaires and the Phenol-Explorer database.
Body weight was obtained at recruitment and after a mean
follow-up time of 5 years. Associations were estimated using
multilevel mixed linear regression models. From 91
polyphenols included, the majority (n = 67) were inversely
associated with 5-year body weight change after
FDR-correction (q < 0.05). The greatest inverse associations
were observed for quercetin 3-O-rhamnoside (change in weight
for doubling in intake: -0.071 $(95\%$ CI: -0.085; -0.056)
kg/5 years). Only 13 polyphenols showed positive
associations with body weight gain, mainly from the subclass
hydroxycinnamic acids (HCAs) with coffee as the main dietary
source, such as 4-caffeoylquinic acid (0.029 $(95\%$ CI:
0.021; 0.038) kg/5 years). Individual polyphenols with
fruit, tea, cocoa and whole grain cereals as the main
dietary sources may contribute to body weight maintenance in
adults. Individual HCAs may have different roles in body
weight change depending on their dietary source.},
keywords = {EPIC (Other) / body weight (Other) / cohort (Other) /
intake (Other) / obesity (Other) / polyphenol (Other)},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:36552633},
pmc = {pmc:PMC9774775},
doi = {10.3390/antiox11122425},
url = {https://inrepo02.dkfz.de/record/186465},
}