Journal Article

DKFZ-2022-03186

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort.

Gil-Lespinard, M. ; Castañeda, J. ; Almanza-Aguilera, E. ; Gómez, J. H. ; Tjønneland, A. ; Kyrø, C. ; Overvad, K. ; Katzke, V.DKFZ* ; Schulze, M. B. ; Masala, G. ; Agnoli, C. ; Santucci de Magistris, M. ; Tumino, R. ; Sacerdote, C. ; Skeie, G. ; Lasheras, C. ; Molina-Montes, E. ; Huerta, J. M. ; Barricarte, A. ; Amiano, P. ; Sonestedt, E. ; da Silva, M. ; Johansson, I. ; Hultdin, J. ; May, A. M. ; Forouhi, N. G. ; Heath, A. K. ; Freisling, H. ; Weiderpass, E. ; Scalbert, A. ; Zamora-Ros, R.

2022
MDPI Basel

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/antiox11122425

Abstract: Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.

Keyword(s): EPIC ; body weight ; cohort ; intake ; obesity ; polyphenol

---

Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

---

Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---