%0 Journal Article
%A Lindley, Clara L
%A Gigic, Biljana
%A Peoples, Anita R
%A Han, Claire J
%A Lin, Tengda
%A Himbert, Caroline
%A Warby, Christy A
%A Boehm, Juergen
%A Hardikar, Sheetal
%A Ashworth, Anjelica
%A Schneider, Martin
%A Ulrich, Alexis
%A Schrotz-King, Petra
%A Figueiredo, Jane C
%A Li, Christopher I
%A Shibata, David
%A Siegel, Erin M
%A Toriola, Adetunji T
%A Ulrich, Cornelia M
%A Syrjala, Karen L
%A Ose, Jennifer
%T Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: Results from the ColoCare Study.
%J Cancer epidemiology, biomarkers & prevention
%V 32
%N 3
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2023-00020
%P 363–370
%D 2023
%X Colorectal cancer (CRC) patients commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score.N=315 patients (stage I-IV) from 2 centers of the ColoCare Study were included: Huntsman Cancer Institute and University of Heidelberg. Biomarkers (e.g., IL-6, VEGF-A, VEGF-D) were measured in serum collected pre-surgery and 12 months thereafter. The CTXD overall score and 4 subscales were collected 12 months after surgery and dichotomized to investigate biomarkers as predictors of distress 12 months after surgery; adjusted for age, sex, body mass index, tumor stage, center, and baseline levels of biomarkers.Doubling of IL-6 predicted future increased risk of overall distress (Odds Ratio (OR) = 1.20; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36595657
%R 10.1158/1055-9965.EPI-22-0882
%U https://inrepo02.dkfz.de/record/186571