Journal Article

DKFZ-2023-00020

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: Results from the ColoCare Study.

Lindley, C. L. ; Gigic, B. ; Peoples, A. R. ; Han, C. J. ; Lin, T. ; Himbert, C. ; Warby, C. A. ; Boehm, J. ; Hardikar, S. ; Ashworth, A. ; Schneider, M. ; Ulrich, A. ; Schrotz-King, P.DKFZ* ; Figueiredo, J. C. ; Li, C. I. ; Shibata, D. ; Siegel, E. M. ; Toriola, A. T. ; Ulrich, C. M. ; Syrjala, K. L. ; Ose, J.

2023
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-22-0882

Abstract: Colorectal cancer (CRC) patients commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score.N=315 patients (stage I-IV) from 2 centers of the ColoCare Study were included: Huntsman Cancer Institute and University of Heidelberg. Biomarkers (e.g., IL-6, VEGF-A, VEGF-D) were measured in serum collected pre-surgery and 12 months thereafter. The CTXD overall score and 4 subscales were collected 12 months after surgery and dichotomized to investigate biomarkers as predictors of distress 12 months after surgery; adjusted for age, sex, body mass index, tumor stage, center, and baseline levels of biomarkers.Doubling of IL-6 predicted future increased risk of overall distress (Odds Ratio (OR) = 1.20; 95%Confidence Interval (CI) = 1.02-1.41; p = 0.03). VEGF-A predicted future increased risk of high family strain (VEGF-A: OR=1.21; 95%CI=1.01-1.44; p=0.04) and VEGF-D was associated with medical and financial demands (OR=1.34; 95%CI=1.01-1.74; p=0.03).This is the first study to show that systemic biomarkers are significantly associated with future CTXD score. Distress was not measured at baseline; we cannot rule out ongoing associations of inflammation and distress throughout treatment versus a direct effect of inflammation on distress. Nonetheless these data add to evidence that biobehavioral processes interact and that systemic biomarkers are associated with cancer-related distress one year after surgery.Exercise and diet interventions that lower systemic cytokine levels may impact longer term CTXD score and improve quality of life of CRC patients.

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Contributing Institute(s):

1. Präventive Onkologie (C120)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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