TY  - JOUR
AU  - Lindley, Clara L
AU  - Gigic, Biljana
AU  - Peoples, Anita R
AU  - Han, Claire J
AU  - Lin, Tengda
AU  - Himbert, Caroline
AU  - Warby, Christy A
AU  - Boehm, Juergen
AU  - Hardikar, Sheetal
AU  - Ashworth, Anjelica
AU  - Schneider, Martin
AU  - Ulrich, Alexis
AU  - Schrotz-King, Petra
AU  - Figueiredo, Jane C
AU  - Li, Christopher I
AU  - Shibata, David
AU  - Siegel, Erin M
AU  - Toriola, Adetunji T
AU  - Ulrich, Cornelia M
AU  - Syrjala, Karen L
AU  - Ose, Jennifer
TI  - Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: Results from the ColoCare Study.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 32
IS  - 3
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2023-00020
SP  - 363–370
PY  - 2023
AB  - Colorectal cancer (CRC) patients commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score.N=315 patients (stage I-IV) from 2 centers of the ColoCare Study were included: Huntsman Cancer Institute and University of Heidelberg. Biomarkers (e.g., IL-6, VEGF-A, VEGF-D) were measured in serum collected pre-surgery and 12 months thereafter. The CTXD overall score and 4 subscales were collected 12 months after surgery and dichotomized to investigate biomarkers as predictors of distress 12 months after surgery; adjusted for age, sex, body mass index, tumor stage, center, and baseline levels of biomarkers.Doubling of IL-6 predicted future increased risk of overall distress (Odds Ratio (OR) = 1.20; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:36595657
DO  - DOI:10.1158/1055-9965.EPI-22-0882
UR  - https://inrepo02.dkfz.de/record/186571
ER  -