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@ARTICLE{Lindley:186571,
      author       = {C. L. Lindley and B. Gigic and A. R. Peoples and C. J. Han
                      and T. Lin and C. Himbert and C. A. Warby and J. Boehm and
                      S. Hardikar and A. Ashworth and M. Schneider and A. Ulrich
                      and P. Schrotz-King$^*$ and J. C. Figueiredo and C. I. Li
                      and D. Shibata and E. M. Siegel and A. T. Toriola and C. M.
                      Ulrich and K. L. Syrjala and J. Ose},
      title        = {{P}re-surgery inflammatory and angiogenesis biomarkers as
                      predictors of 12-month cancer-related distress: {R}esults
                      from the {C}olo{C}are {S}tudy.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {32},
      number       = {3},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2023-00020},
      pages        = {363–370},
      year         = {2023},
      abstract     = {Colorectal cancer (CRC) patients commonly suffer from
                      complex psychological distress. Elevated distress may be
                      linked to systemic biomarkers. We investigated associations
                      of biomarkers of inflammation and angiogenesis with
                      cancer-related distress (CTXD) score.N=315 patients (stage
                      I-IV) from 2 centers of the ColoCare Study were included:
                      Huntsman Cancer Institute and University of Heidelberg.
                      Biomarkers (e.g., IL-6, VEGF-A, VEGF-D) were measured in
                      serum collected pre-surgery and 12 months thereafter. The
                      CTXD overall score and 4 subscales were collected 12 months
                      after surgery and dichotomized to investigate biomarkers as
                      predictors of distress 12 months after surgery; adjusted for
                      age, sex, body mass index, tumor stage, center, and baseline
                      levels of biomarkers.Doubling of IL-6 predicted future
                      increased risk of overall distress (Odds Ratio (OR) = 1.20;
                      $95\%Confidence$ Interval (CI) = 1.02-1.41; p = 0.03).
                      VEGF-A predicted future increased risk of high family strain
                      (VEGF-A: OR=1.21; $95\%CI=1.01-1.44;$ p=0.04) and VEGF-D was
                      associated with medical and financial demands (OR=1.34;
                      $95\%CI=1.01-1.74;$ p=0.03).This is the first study to show
                      that systemic biomarkers are significantly associated with
                      future CTXD score. Distress was not measured at baseline; we
                      cannot rule out ongoing associations of inflammation and
                      distress throughout treatment versus a direct effect of
                      inflammation on distress. Nonetheless these data add to
                      evidence that biobehavioral processes interact and that
                      systemic biomarkers are associated with cancer-related
                      distress one year after surgery.Exercise and diet
                      interventions that lower systemic cytokine levels may impact
                      longer term CTXD score and improve quality of life of CRC
                      patients.},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36595657},
      doi          = {10.1158/1055-9965.EPI-22-0882},
      url          = {https://inrepo02.dkfz.de/record/186571},
}