Home > Publications database > Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: Results from the ColoCare Study. > print

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100 1 _ |a Lindley, Clara L
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245 _ _ |a Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: Results from the ColoCare Study.
260 _ _ |a Philadelphia, Pa.
|c 2023
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520 _ _ |a Colorectal cancer (CRC) patients commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score.N=315 patients (stage I-IV) from 2 centers of the ColoCare Study were included: Huntsman Cancer Institute and University of Heidelberg. Biomarkers (e.g., IL-6, VEGF-A, VEGF-D) were measured in serum collected pre-surgery and 12 months thereafter. The CTXD overall score and 4 subscales were collected 12 months after surgery and dichotomized to investigate biomarkers as predictors of distress 12 months after surgery; adjusted for age, sex, body mass index, tumor stage, center, and baseline levels of biomarkers.Doubling of IL-6 predicted future increased risk of overall distress (Odds Ratio (OR) = 1.20; 95%Confidence Interval (CI) = 1.02-1.41; p = 0.03). VEGF-A predicted future increased risk of high family strain (VEGF-A: OR=1.21; 95%CI=1.01-1.44; p=0.04) and VEGF-D was associated with medical and financial demands (OR=1.34; 95%CI=1.01-1.74; p=0.03).This is the first study to show that systemic biomarkers are significantly associated with future CTXD score. Distress was not measured at baseline; we cannot rule out ongoing associations of inflammation and distress throughout treatment versus a direct effect of inflammation on distress. Nonetheless these data add to evidence that biobehavioral processes interact and that systemic biomarkers are associated with cancer-related distress one year after surgery.Exercise and diet interventions that lower systemic cytokine levels may impact longer term CTXD score and improve quality of life of CRC patients.
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700 1 _ |a Gigic, Biljana
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700 1 _ |a Peoples, Anita R
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700 1 _ |a Han, Claire J
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700 1 _ |a Lin, Tengda
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700 1 _ |a Himbert, Caroline
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700 1 _ |a Warby, Christy A
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700 1 _ |a Boehm, Juergen
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700 1 _ |a Hardikar, Sheetal
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700 1 _ |a Ashworth, Anjelica
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700 1 _ |a Schneider, Martin
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700 1 _ |a Ulrich, Alexis
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700 1 _ |a Schrotz-King, Petra
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700 1 _ |a Figueiredo, Jane C
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700 1 _ |a Li, Christopher I
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700 1 _ |a Shibata, David
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700 1 _ |a Siegel, Erin M
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700 1 _ |a Toriola, Adetunji T
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700 1 _ |a Ulrich, Cornelia M
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700 1 _ |a Syrjala, Karen L
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700 1 _ |a Ose, Jennifer
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