Journal Article (Review Article)

DKFZ-2023-00024

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The roles of proteases in prostate cancer.

Koistinen, H. ; Kovanen, R.-M. ; Hollenberg, M. D. ; Dufour, A. ; Radisky, E. S. ; Stenman, U.-H. ; Batra, J. ; Clements, J. ; Hooper, J. D. ; Diamandis, E. ; Schilling, O.DKFZ* ; Rannikko, A. ; Mirtti, T.

2023
Wiley-VCH Weinheim [u.a.]

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Please use a persistent id in citations: doi:10.1002/iub.2700

Abstract: Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many of the most well-characterized members of this enzyme family are regulated by androgens, hormones essential for development of prostate cancer. Most notably, several kallikrein-related peptidases, including KLK3 (prostate-specific antigen, PSA), the most well-known prostate cancer marker, and type II transmembrane serine proteases, such as TMPRSS2 and matriptase, have been extensively studied and found to promote prostate cancer progression. Recent findings also suggest a critical role for proteases in the development of advanced and aggressive castration-resistant prostate cancer (CRPC). Perhaps the most intriguing evidence for this role comes from studies showing that the protease-activated transmembrane proteins, Notch and CDCP1, are associated with the development of CRPC. Here, we review the roles of proteases in prostate cancer, with a special focus on their regulation by androgens.

Keyword(s): AR ; CDCP1 ; CUB domain-containing protein 1 ; FAP ; KLK ; MMP ; Notch ; PAR ; TMPRSS2 ; androgen ; androgen receptor ; fibroblast activation protein ; hepsin ; kallikrein-related peptidases ; matriptase ; matrix metalloproteinase ; peptidases ; prostate cancer ; protease-activated receptor ; proteases ; trypsin ; uPA ; urokinase-type plasminogen activator

Note: 2023 Jun;75(6):493-513

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Contributing Institute(s):

1. DKTK FR zentral (FR01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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