Journal Article

DKFZ-2023-00038

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A phase II clinical trial of combined BRAF/MEK inhibition for BRAFV600E-mutated multiple myeloma.

Giesen, N. (First author)DKFZ* ; Chatterjee, M. ; Scheid, C. ; Poos, A. M. ; Besemer, B. ; Miah, K.DKFZ* ; Benner, A.DKFZ* ; Becker, N. ; Moehler, T. ; Metzler, I. ; Khandanpour, C. ; Seidel-Glaetzer, A. ; Trautmann-Grill, K. ; Kortüm, K. M. ; Müller-Tidow, C. ; Mechtersheimer, G. ; Goeppert, B. ; Stenzinger, A. ; Weinhold, N. ; Goldschmidt, H. ; Weisel, K. C. ; Raab, M.-S. (Last author)DKFZ*

2023
American Society of Hematology Washington, DC

This record in other databases:  

Please use a persistent id in citations: doi:10.1182/blood.2022017789

Abstract: Activating BRAF mutations are found in a small subset of patients with newly diagnosed multiple myeloma but prevalence increases in late stage, refractory disease, and are associated with adverse outcome. This prospective single-arm, open-label, multicenter phase II trial assessed the efficacy and safety of combined BRAF/MEK inhibition, using encorafenib and binimetinib, in patients with relapsed/refractory multiple myeloma (RRMM) carrying a BRAFV600E mutation (ClinicalTrials.gov identifier: NCT02834364). Patients received 450 mg encorafenib once daily and binimetinib 45 mg twice daily. The primary end point was the overall response rate achieved within the first year after start of treatment according to IMWG criteria. Twelve RRMM patients with a median of 5 prior lines of therapy were enrolled. The overall response rate was 83.3% with 10 patients achieving at least a partial response. The median progression-free survival (PFS) was 5.6 months and overall survival was 55% at 24 months. Emerging resistance to therapy was driven by RAS mutations and structural variants involving the BRAF locus. This is the first prospective clinical trial to demonstrate that combined BRAF/MEK inhibition is highly effective in patients with BRAFV600E mutated RRMM and represents a successful targeted precision medicine approach in this disease.

Note: #EA:A360#LA:A360# / 2023 Apr 6;141(14):1685-1690

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Contributing Institute(s):

1. KKE Mol. Hämatologie/Onkologie (A360)
2. C060 Biostatistik (C060)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 20 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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