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@ARTICLE{Casalone:186686,
      author       = {E. Casalone and G. Birolo and B. Pardini and A. Allione and
                      A. Russo and C. Catalano and M. Mencoboni and D. Ferrante
                      and C. Magnani and M. Sculco and I. Dianzani and F. Grosso
                      and D. Mirabelli and R. A. Filiberti and O. Rena and C.
                      Sacerdote and M. Rodriguez-Barranco and K. Smith-Byrne and
                      S. Panico and C. Agnoli and T. Johnson$^*$ and R. Kaaks$^*$
                      and R. Tumino and J. M. Huerta and E. Riboli and A. K. Heath
                      and C. Trobajo-Sanmartín and M. B. Schulze and C. Saieva
                      and P. Amiano and A. Agudo and E. Weiderpass and P. Vineis
                      and G. Matullo},
      title        = {{S}erum {E}xtracellular {V}esicle-{D}erived micro{RNA}s as
                      {P}otential {B}iomarkers for {P}leural {M}esothelioma in a
                      {E}uropean {P}rospective {S}tudy.},
      journal      = {Cancers},
      volume       = {15},
      number       = {1},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00055},
      pages        = {125},
      year         = {2023},
      abstract     = {Malignant pleural mesothelioma (MPM) is an aggressive
                      cancer with a dismal prognosis. Early therapeutic
                      interventions could improve patient outcomes. We aimed to
                      identify a pattern of microRNAs (miRNAs) as potential early
                      non-invasive markers of MPM. In a case-control study nested
                      in the European Prospective Investigation into Cancer and
                      Nutrition cohort, we screened the whole miRNome in serum
                      extracellular vesicles (EVs) of preclinical MPM cases. In a
                      subgroup of 20 preclinical samples collected five years
                      prior MPM diagnosis, we observed an upregulation of
                      miR-11400 (fold change (FC) = 2.6, adjusted p-value = 0.01),
                      miR-148a-3p (FC = 1.5, p-value = 0.001), and miR-409-3p (FC
                      = 1.5, p-value = 0.04) relative to matched controls. The
                      3-miRNA panel showed a good classification capacity with an
                      area under the receiver operating characteristic curve (AUC)
                      of 0.81 (specificity = 0.75, sensitivity = 0.70). The
                      diagnostic ability of the model was also evaluated in an
                      independent retrospective cohort, yielding a higher
                      predictive power (AUC = 0.86). A signature of EV miRNA can
                      be detected up to five years before MPM; moreover, the
                      identified miRNAs could provide functional insights into the
                      molecular changes related to the late carcinogenic process,
                      preceding MPM development.},
      keywords     = {biomarkers (Other) / early changes (Other) / malignant
                      pleural mesothelioma (Other) / microRNAs (Other) / next
                      generation sequencing (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36612122},
      doi          = {10.3390/cancers15010125},
      url          = {https://inrepo02.dkfz.de/record/186686},
}