Journal Article

DKFZ-2023-00055

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Serum Extracellular Vesicle-Derived microRNAs as Potential Biomarkers for Pleural Mesothelioma in a European Prospective Study.

Casalone, E. ; Birolo, G. ; Pardini, B. ; Allione, A. ; Russo, A. ; Catalano, C. ; Mencoboni, M. ; Ferrante, D. ; Magnani, C. ; Sculco, M. ; Dianzani, I. ; Grosso, F. ; Mirabelli, D. ; Filiberti, R. A. ; Rena, O. ; Sacerdote, C. ; Rodriguez-Barranco, M. ; Smith-Byrne, K. ; Panico, S. ; Agnoli, C. ; Johnson, T.DKFZ* ; Kaaks, R.DKFZ* ; Tumino, R. ; Huerta, J. M. ; Riboli, E. ; Heath, A. K. ; Trobajo-Sanmartín, C. ; Schulze, M. B. ; Saieva, C. ; Amiano, P. ; Agudo, A. ; Weiderpass, E. ; Vineis, P. ; Matullo, G.

2023
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers15010125

Abstract: Malignant pleural mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Early therapeutic interventions could improve patient outcomes. We aimed to identify a pattern of microRNAs (miRNAs) as potential early non-invasive markers of MPM. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort, we screened the whole miRNome in serum extracellular vesicles (EVs) of preclinical MPM cases. In a subgroup of 20 preclinical samples collected five years prior MPM diagnosis, we observed an upregulation of miR-11400 (fold change (FC) = 2.6, adjusted p-value = 0.01), miR-148a-3p (FC = 1.5, p-value = 0.001), and miR-409-3p (FC = 1.5, p-value = 0.04) relative to matched controls. The 3-miRNA panel showed a good classification capacity with an area under the receiver operating characteristic curve (AUC) of 0.81 (specificity = 0.75, sensitivity = 0.70). The diagnostic ability of the model was also evaluated in an independent retrospective cohort, yielding a higher predictive power (AUC = 0.86). A signature of EV miRNA can be detected up to five years before MPM; moreover, the identified miRNAs could provide functional insights into the molecular changes related to the late carcinogenic process, preceding MPM development.

Keyword(s): biomarkers ; early changes ; malignant pleural mesothelioma ; microRNAs ; next generation sequencing

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
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