Journal Article (Review Article)

DKFZ-2023-00064

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiotheranostics in oncology: Making precision medicine possible.

Aboagye, E. O. ; Barwick, T. D. ; Haberkorn, U. (Last author)DKFZ*

2023
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.3322/caac.21768

Abstract: A quintessential setting for precision medicine, theranostics refers to a rapidly evolving field of medicine in which disease is diagnosed followed by treatment of disease-positive patients using tools for the therapy identical or similar to those used for the diagnosis. Against the backdrop of only-treat-when-visualized, the goal is a high therapeutic index with efficacy markedly surpassing toxicity. Oncology leads the way in theranostics innovation, where the approach has become possible with the identification of unique proteins and other factors selectively expressed in cancer versus healthy tissue, advances in imaging technology able to report these tissue factors, and major understanding of targeting chemicals and nanodevices together with methods to attach labels or warheads for imaging and therapy. Radiotheranostics-using radiopharmaceuticals-is becoming routine in patients with prostate cancer and neuroendocrine tumors who express the proteins PSMA (prostate-specific membrane antigen) and SSTR2 (somatostatin receptor 2), respectively, on their cancer. The palpable excitement in the field stems from the finding that a proportion of patients with large metastatic burden show complete and partial responses, and this outcome is catalyzing the search for more radiotheranostics approaches. Not every patient will benefit from radiotheranostics; but, for those who cross the target-detected line, the likelihood of response is very high.

Keyword(s): metastatic cancer ; molecularly targeted therapies ; nuclear medicine ; pharmacology ; positron emission tomography ; radioisotopes ; radiotheranostics ; theranostics audit trail

Note: #LA:E060# / 2023 May-Jun;73(3):255-274

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Contributing Institute(s):

1. E060 KKE Nuklearmedizin (E060)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 90 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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