Journal Article (Review Article)

DKFZ-2023-00117

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis.

Szabó, A. ; Váncsa, S. ; Hegyi, P. ; Váradi, A. ; Forintos, A. ; Filipov, T. ; Ács, J. ; Ács, N. ; Szarvas, T.DKFZ* ; Nyirády, P. ; Kopa, Z.

2023
Biomed Central London

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Please use a persistent id in citations: doi:10.1186/s12958-023-01054-0

Abstract: Infertility affects one in every six couples in developed countries, and approximately 50% is of male origin. In 2021, sperm DNA fragmentation (SDF) testing became an evidence-based test for fertility evaluations depicting fertility more clearly than standard semen parameters. Therefore, we aimed to summarize the potential prognostic factors of a higher SDF.We conducted a systematic search in three medical databases and included studies investigating any risk factors for SDF values. We calculated mean differences (MD) in SDF with 95% confidence interval (CI) for exposed and non-exposed individuals.We included 190 studies in our analysis. In the group of associated health conditions, varicocele (MD = 13.62%, CI: 9.39-17.84) and impaired glucose tolerance (MD = 13.75%, CI: 6.99-20.51) had the most significant increase in SDF. Among malignancies, testicular tumors had the highest impact, with a maximum of MD = 11.3% (CI: 7.84-14.76). Among infections, the overall effects of both Chlamydia and HPV were negligible. Of lifestyle factors, smoking had the most disruptive effect on SDF - an increase of 9.19% (CI: 4.33-14.06). Different periods of sexual abstinence did not show significant variations in SDF values. Age seemed to have a more drastic effect on SDF from age 50 onwards, with a mean difference of 12.58% (CI: 7.31-17.86). Pollution also had a detrimental effect - 9.68% (CI: 6.85-12.52).Of the above risk factors, varicocele, impaired glucose tolerance, testicular tumors, smoking, pollution, and paternal age of over 50 were associated with the highest SDF.CRD42021282533.

Keyword(s): DFI ; DNA fragmentation index ; Infertility ; Male fertility ; Prognostic factors ; Reproductive medicine ; SDF ; Sperm DNA fragmentation ; Sperm quality

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Contributing Institute(s):

1. DKTK ED ES zentral (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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