TY  - JOUR
AU  - Tessonnier, Thomas
AU  - Ecker, Swantje
AU  - Besuglow, Judith
AU  - Naumann, Jakob
AU  - Mein, Stewart
AU  - Longarino, Friderike K
AU  - Ellerbrock, Malte
AU  - Ackermann, Benjamin
AU  - Winter, Marcus
AU  - Brons, Stephan
AU  - Qubala, Abdallah
AU  - Haberer, Thomas
AU  - Debus, Jürgen
AU  - Jäkel, Oliver
AU  - Mairani, Andrea
TI  - Commissioning of helium ion therapy and the first patient treatment with active beam delivery.
JO  - International journal of radiation oncology, biology, physics
VL  - 116
IS  - 4
SN  - 0360-3016
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-00134
SP  - 935-948
PY  - 2023
N1  - #EA:E050#LA:E050#LA:E040# / 2023 Jul 15;116(4):935-948
AB  - Helium ions offer intermediate physical and biological properties to the clinically used protons and carbon ions. This work presents the commissioning of the first clinical treatment planning system (TPS) for helium ion therapy with active beam delivery to prepare the first patients' treatment at the INSTITUTION-XXX METHODS: : Through collaboration between RaySearch Laboratories and INSTITUTION-XXX, absorbed and relative biological effectiveness (RBE)-weighted calculation methods were integrated for helium ion beam therapy with raster-scanned delivery in the TPS RayStation. At INSTITUTION-XXX, a modified Microdosimetric Kinetic biological Model was chosen as reference biological model. TPS absorbed dose predictions were compared against measurements with several devices, using phantoms of different complexities, from homogeneous to heterogeneous anthropomorphic phantoms. RBE and RBE-weighted dose predictions of the TPS were verified against calculations with an independent RBE-weighted dose engine. The patient specific quality-assurance of the first treatment at INSTITUTION-XXX using helium ion beam with raster-scanned delivery is presented considering standard patient-specific measurements in a water phantom and two independent dose calculations with a Monte-Carlo or an analytical-based engine.TPS predictions were consistent with dosimetric measurements and independent dose engines computations for absorbed and RBE-weighted doses. The mean difference between dose measurements to the TPS calculation was 0.2
KW  - Helium ions (Other)
KW  - Treatment planning system (Other)
KW  - commissioning (Other)
KW  - particle therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36681200
DO  - DOI:10.1016/j.ijrobp.2023.01.015
UR  - https://inrepo02.dkfz.de/record/212415
ER  -