Journal Article

DKFZ-2023-00134

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Commissioning of helium ion therapy and the first patient treatment with active beam delivery.

Tessonnier, T. (First author)Extern* ; Ecker, S. ; Besuglow, J.DKFZ* ; Naumann, J. ; Mein, S.DKFZ* ; Longarino, F. K.DKFZ* ; Ellerbrock, M. ; Ackermann, B. ; Winter, M. ; Brons, S. ; Qubala, A. ; Haberer, T. ; Debus, J.DKFZ* ; Jäkel, O. (Last author)DKFZ* ; Mairani, A. (Last author)DKFZ*

2023
Elsevier Science Amsterdam [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.ijrobp.2023.01.015

Abstract: Helium ions offer intermediate physical and biological properties to the clinically used protons and carbon ions. This work presents the commissioning of the first clinical treatment planning system (TPS) for helium ion therapy with active beam delivery to prepare the first patients' treatment at the INSTITUTION-XXX METHODS: : Through collaboration between RaySearch Laboratories and INSTITUTION-XXX, absorbed and relative biological effectiveness (RBE)-weighted calculation methods were integrated for helium ion beam therapy with raster-scanned delivery in the TPS RayStation. At INSTITUTION-XXX, a modified Microdosimetric Kinetic biological Model was chosen as reference biological model. TPS absorbed dose predictions were compared against measurements with several devices, using phantoms of different complexities, from homogeneous to heterogeneous anthropomorphic phantoms. RBE and RBE-weighted dose predictions of the TPS were verified against calculations with an independent RBE-weighted dose engine. The patient specific quality-assurance of the first treatment at INSTITUTION-XXX using helium ion beam with raster-scanned delivery is presented considering standard patient-specific measurements in a water phantom and two independent dose calculations with a Monte-Carlo or an analytical-based engine.TPS predictions were consistent with dosimetric measurements and independent dose engines computations for absorbed and RBE-weighted doses. The mean difference between dose measurements to the TPS calculation was 0.2% for spread-out Bragg peaks in water. Verification of the first patient treatment TPS predictions against independent engines for both absorbed and RBE-weighted doses presents differences within 2% in the target and with a maximum deviation of 3.5% in the investigated critical regions of interest.Helium ion beam therapy has been successfully commissioned and introduced into clinical use. Through comprehensive validation of the absorbed and RBE-weighted dose predictions of the RayStation TPS, the first clinical TPS for helium ion therapy using raster-scanned delivery was employed to plan the first helium patient treatment at INSTITUTION-XXX.

Keyword(s): Helium ions ; Treatment planning system ; commissioning ; particle therapy

Note: #EA:E050#LA:E050#LA:E040# / 2023 Jul 15;116(4):935-948

---

Contributing Institute(s):

1. E050 KKE Strahlentherapie (E050)
2. E040 Med. Physik in der Strahlentherapie (E040)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---