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@ARTICLE{Tessonnier:212415,
      author       = {T. Tessonnier and S. Ecker and J. Besuglow$^*$ and J.
                      Naumann and S. Mein$^*$ and F. K. Longarino$^*$ and M.
                      Ellerbrock and B. Ackermann and M. Winter and S. Brons and
                      A. Qubala and T. Haberer and J. Debus$^*$ and O. Jäkel$^*$
                      and A. Mairani$^*$},
      title        = {{C}ommissioning of helium ion therapy and the first patient
                      treatment with active beam delivery.},
      journal      = {International journal of radiation oncology, biology,
                      physics},
      volume       = {116},
      number       = {4},
      issn         = {0360-3016},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-00134},
      pages        = {935-948},
      year         = {2023},
      note         = {#EA:E050#LA:E050#LA:E040# / 2023 Jul 15;116(4):935-948},
      abstract     = {Helium ions offer intermediate physical and biological
                      properties to the clinically used protons and carbon ions.
                      This work presents the commissioning of the first clinical
                      treatment planning system (TPS) for helium ion therapy with
                      active beam delivery to prepare the first patients'
                      treatment at the INSTITUTION-XXX METHODS: : Through
                      collaboration between RaySearch Laboratories and
                      INSTITUTION-XXX, absorbed and relative biological
                      effectiveness (RBE)-weighted calculation methods were
                      integrated for helium ion beam therapy with raster-scanned
                      delivery in the TPS RayStation. At INSTITUTION-XXX, a
                      modified Microdosimetric Kinetic biological Model was chosen
                      as reference biological model. TPS absorbed dose predictions
                      were compared against measurements with several devices,
                      using phantoms of different complexities, from homogeneous
                      to heterogeneous anthropomorphic phantoms. RBE and
                      RBE-weighted dose predictions of the TPS were verified
                      against calculations with an independent RBE-weighted dose
                      engine. The patient specific quality-assurance of the first
                      treatment at INSTITUTION-XXX using helium ion beam with
                      raster-scanned delivery is presented considering standard
                      patient-specific measurements in a water phantom and two
                      independent dose calculations with a Monte-Carlo or an
                      analytical-based engine.TPS predictions were consistent with
                      dosimetric measurements and independent dose engines
                      computations for absorbed and RBE-weighted doses. The mean
                      difference between dose measurements to the TPS calculation
                      was $0.2\%$ for spread-out Bragg peaks in water.
                      Verification of the first patient treatment TPS predictions
                      against independent engines for both absorbed and
                      RBE-weighted doses presents differences within $2\%$ in the
                      target and with a maximum deviation of $3.5\%$ in the
                      investigated critical regions of interest.Helium ion beam
                      therapy has been successfully commissioned and introduced
                      into clinical use. Through comprehensive validation of the
                      absorbed and RBE-weighted dose predictions of the RayStation
                      TPS, the first clinical TPS for helium ion therapy using
                      raster-scanned delivery was employed to plan the first
                      helium patient treatment at INSTITUTION-XXX.},
      keywords     = {Helium ions (Other) / Treatment planning system (Other) /
                      commissioning (Other) / particle therapy (Other)},
      cin          = {E050 / E040 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)E050-20160331 / I:(DE-He78)E040-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36681200},
      doi          = {10.1016/j.ijrobp.2023.01.015},
      url          = {https://inrepo02.dkfz.de/record/212415},
}