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@ARTICLE{Gambichler:212426,
      author       = {T. Gambichler and L. G. Brüggestrat and M. Skrygan and C.
                      H. Scheel and L. Susok and J. Becker$^*$},
      title        = {{T}he {A}ntineoplastic {E}ffect of {D}imethyl {F}umarate on
                      {V}irus-{N}egative {M}erkel {C}ell {C}arcinoma {C}ell
                      {L}ines: {P}reliminary {R}esults.},
      journal      = {Cancers},
      volume       = {15},
      number       = {2},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00145},
      pages        = {547},
      year         = {2023},
      abstract     = {Merkel cell carcinoma (MCC) is a rare, difficult-to-treat
                      skin cancer once immunotherapy has failed. MCC is associated
                      either with the clonal integration of the Merkel cell
                      polyomavirus (MCPyV) or mutagenic UV-radiation. Fumaric acid
                      esters, including dimethyl fumarate (DMF), have been shown
                      to inhibit cell growth in cutaneous melanoma and lymphoma.
                      We aimed to explore the effects of DMF on MCPyV-negative MCC
                      cell lines. Three MCC cell lines (MCC13, MCC14.2, and MCC26)
                      were treated with different doses of DMF. The cytotoxic
                      effects and cell proliferation were assessed by the MTT
                      cytotoxicity assay and BrdU proliferation assay at different
                      time points. A significant reduction in cell viability and
                      proliferation were demonstrated for all the cell lines used,
                      with DMF proving to be effective.},
      keywords     = {dimethyl fumarate (Other) / fumaric acid esters (Other) /
                      merkel cell carcinoma (Other) / monomethyl fumarate (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36672496},
      pmc          = {pmc:PMC9857057},
      doi          = {10.3390/cancers15020547},
      url          = {https://inrepo02.dkfz.de/record/212426},
}