Journal Article

DKFZ-2023-00145

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Antineoplastic Effect of Dimethyl Fumarate on Virus-Negative Merkel Cell Carcinoma Cell Lines: Preliminary Results.

Gambichler, T. ; Brüggestrat, L. G. ; Skrygan, M. ; Scheel, C. H. ; Susok, L. ; Becker, J.DKFZ*

2023
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers15020547

Abstract: Merkel cell carcinoma (MCC) is a rare, difficult-to-treat skin cancer once immunotherapy has failed. MCC is associated either with the clonal integration of the Merkel cell polyomavirus (MCPyV) or mutagenic UV-radiation. Fumaric acid esters, including dimethyl fumarate (DMF), have been shown to inhibit cell growth in cutaneous melanoma and lymphoma. We aimed to explore the effects of DMF on MCPyV-negative MCC cell lines. Three MCC cell lines (MCC13, MCC14.2, and MCC26) were treated with different doses of DMF. The cytotoxic effects and cell proliferation were assessed by the MTT cytotoxicity assay and BrdU proliferation assay at different time points. A significant reduction in cell viability and proliferation were demonstrated for all the cell lines used, with DMF proving to be effective.

Keyword(s): dimethyl fumarate ; fumaric acid esters ; merkel cell carcinoma ; monomethyl fumarate

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Contributing Institute(s):

1. DKTK ED ES zentral (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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