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@ARTICLE{Huemer:212515,
      author       = {M.-T. Huemer and A. Kluttig and B. Fischer and W. Ahrens
                      and S. Castell and N. Ebert and S. Gastell and K.-H. Jöckel
                      and R. Kaaks$^*$ and A. Karch and T. Keil and Y. Kemmling
                      and L. Krist and M. Leitzmann and W. Lieb and C.
                      Meinke-Franze and K. B. Michels and R. Mikolajczyk and I.
                      Moreno Velásquez and T. Pischon and S. Schipf and B.
                      Schmidt and B. Schöttker$^*$ and M. B. Schulze and H.
                      Stocker$^*$ and H. Teismann and K. Wirkner and M. Drey and
                      A. Peters and B. Thorand},
      title        = {{G}rip strength values and cut-off points based on over
                      200,000 adults of the {G}erman {N}ational {C}ohort - a
                      comparison to the {EWGSOP}2 cut-off points.},
      journal      = {Age $\&$ ageing},
      volume       = {52},
      number       = {1},
      issn         = {0002-0729},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2023-00200},
      pages        = {afac324},
      year         = {2023},
      abstract     = {The European Working Group on Sarcopenia in Older People
                      (EWGSOP) updated in 2018 the cut-off points for low grip
                      strength to assess sarcopenia based on pooled data from 12
                      British studies.Comparison of the EWGSOP2 cut-off points for
                      low grip strength to those derived from a large German
                      sample.We assessed the grip strength distribution across age
                      and derived low grip strength cut-off points for men and
                      women (peak mean -2.5 × SD) based on 200,389 German
                      National Cohort (NAKO) participants aged 19-75 years. In
                      1,012 Cooperative Health Research in the Region of Augsburg
                      (KORA)-Age participants aged 65-93 years, we calculated the
                      age-standardised prevalence of low grip strength and
                      time-dependent sensitivity and specificity for all-cause
                      mortality.Grip strength increased in the third and fourth
                      decade of life and declined afterwards. Calculated cut-off
                      points for low grip strength were 29 kg for men and 18 kg
                      for women. In KORA-Age, the age-standardised prevalence of
                      low grip strength was 1.5× higher for NAKO-derived
                      $(17.7\%)$ compared to EWGSOP2 $(11.7\%)$ cut-off points.
                      NAKO-derived cut-off points yielded a higher sensitivity and
                      lower specificity for all-cause mortality.Cut-off points for
                      low grip strength from German population-based data were 2
                      kg higher than the EWGSOP2 cut-off points. Higher cut-off
                      points increase the sensitivity, thereby suggesting an
                      intervention for more patients at risk, while other
                      individuals might receive additional diagnostics/treatment
                      without the urgent need. Research on the effectiveness of
                      intervention in patients with low grip strength defined by
                      different cut-off points is needed.},
      keywords     = {European Working Group on Sarcopenia in Older People
                      (EWGSOP) (Other) / cut-off points (Other) / grip strength
                      (Other) / mortality (Other) / probable sarcopenia (Other)},
      cin          = {C020 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36702514},
      doi          = {10.1093/ageing/afac324},
      url          = {https://inrepo02.dkfz.de/record/212515},
}