Journal Article

DKFZ-2023-00200

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points.

Huemer, M.-T. ; Kluttig, A. ; Fischer, B. ; Ahrens, W. ; Castell, S. ; Ebert, N. ; Gastell, S. ; Jöckel, K.-H. ; Kaaks, R.DKFZ* ; Karch, A. ; Keil, T. ; Kemmling, Y. ; Krist, L. ; Leitzmann, M. ; Lieb, W. ; Meinke-Franze, C. ; Michels, K. B. ; Mikolajczyk, R. ; Moreno Velásquez, I. ; Pischon, T. ; Schipf, S. ; Schmidt, B. ; Schöttker, B.DKFZ* ; Schulze, M. B. ; Stocker, H.DKFZ* ; Teismann, H. ; Wirkner, K. ; Drey, M. ; Peters, A. ; Thorand, B.

2023
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/ageing/afac324

Abstract: The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies.Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample.We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality.Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality.Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.

Keyword(s): European Working Group on Sarcopenia in Older People (EWGSOP) ; cut-off points ; grip strength ; mortality ; probable sarcopenia

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C070 Klinische Epidemiologie und Alternf. (C070)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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