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000212537 041__ $$aEnglish
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000212537 1001_ $$aSchroeder, Sarah M$$b0
000212537 245__ $$aViral T-cell epitopes - Identification, characterization and clinical application.
000212537 260__ $$aLondon$$bAcademic Press$$c2023
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000212537 520__ $$aT-cell immunity, mediated by CD4+ and CD8+ T cells, represents a cornerstone in the control of viral infections. Virus-derived T-cell epitopes are represented by human leukocyte antigen (HLA)-presented viral peptides on the surface of virus-infected cells. They are the prerequisite for the recognition of infected cells by T cells. Knowledge of viral T-cell epitopes provides on the one hand a diagnostic tool to decipher protective T-cell immune responses in the human population and on the other hand various prophylactic and therapeutic options including vaccination approaches and the transfer of virus-specific T cells. Such approaches have already been proven to be effective against various viral infections, particularly in immunocompromised patients lacking sufficient humoral, antibody-based immune response. This review provides an overview on the state of the art as well as current studies regarding the identification and characterization of viral T-cell epitopes and approaches of clinical application. In the first chapter in silico prediction tools and direct, mass spectrometry-based identification of viral T-cell epitopes is compared. The second chapter provides an overview of commonly used assays for further characterization of T-cell responses and phenotypes. The final chapter presents an overview of clinical application of viral T-cell epitopes with a focus on human immunodeficiency virus (HIV), human cytomegalovirus (HCMV) and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), being representatives of relevant viruses.
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000212537 650_7 $$2Other$$aDC vaccination
000212537 650_7 $$2Other$$aImmunopeptidomics
000212537 650_7 $$2Other$$aIn silico prediction
000212537 650_7 $$2Other$$aMass spectrometry
000212537 650_7 $$2Other$$aPeptide vaccination
000212537 650_7 $$2Other$$aT-cell assays
000212537 650_7 $$2Other$$aT-cell epitope characterization
000212537 650_7 $$2Other$$aT-cell epitopes
000212537 650_7 $$2Other$$aT-cell transfer
000212537 650_7 $$2Other$$aViral infection
000212537 7001_ $$aNelde, Annika$$b1
000212537 7001_ $$0P:(DE-He78)aa8b428f7b1df6694113a5a7d3c4832a$$aWalz, Juliane$$b2$$udkfz
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