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| Home > Publications database > Viral T-cell epitopes - Identification, characterization and clinical application. |
| Journal Article (Review Article) | DKFZ-2023-00222 |
; ;
2023
Academic Press
London
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Please use a persistent id in citations: doi:10.1016/j.smim.2023.101725
Abstract: T-cell immunity, mediated by CD4+ and CD8+ T cells, represents a cornerstone in the control of viral infections. Virus-derived T-cell epitopes are represented by human leukocyte antigen (HLA)-presented viral peptides on the surface of virus-infected cells. They are the prerequisite for the recognition of infected cells by T cells. Knowledge of viral T-cell epitopes provides on the one hand a diagnostic tool to decipher protective T-cell immune responses in the human population and on the other hand various prophylactic and therapeutic options including vaccination approaches and the transfer of virus-specific T cells. Such approaches have already been proven to be effective against various viral infections, particularly in immunocompromised patients lacking sufficient humoral, antibody-based immune response. This review provides an overview on the state of the art as well as current studies regarding the identification and characterization of viral T-cell epitopes and approaches of clinical application. In the first chapter in silico prediction tools and direct, mass spectrometry-based identification of viral T-cell epitopes is compared. The second chapter provides an overview of commonly used assays for further characterization of T-cell responses and phenotypes. The final chapter presents an overview of clinical application of viral T-cell epitopes with a focus on human immunodeficiency virus (HIV), human cytomegalovirus (HCMV) and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), being representatives of relevant viruses.
Keyword(s): DC vaccination ; Immunopeptidomics ; In silico prediction ; Mass spectrometry ; Peptide vaccination ; T-cell assays ; T-cell epitope characterization ; T-cell epitopes ; T-cell transfer ; Viral infection
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