% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schroeder:212537,
      author       = {S. M. Schroeder and A. Nelde and J. Walz$^*$},
      title        = {{V}iral {T}-cell epitopes - {I}dentification,
                      characterization and clinical application.},
      journal      = {Seminars in immunology},
      volume       = {66},
      issn         = {1044-5323},
      address      = {London},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2023-00222},
      pages        = {101725},
      year         = {2023},
      abstract     = {T-cell immunity, mediated by CD4+ and CD8+ T cells,
                      represents a cornerstone in the control of viral infections.
                      Virus-derived T-cell epitopes are represented by human
                      leukocyte antigen (HLA)-presented viral peptides on the
                      surface of virus-infected cells. They are the prerequisite
                      for the recognition of infected cells by T cells. Knowledge
                      of viral T-cell epitopes provides on the one hand a
                      diagnostic tool to decipher protective T-cell immune
                      responses in the human population and on the other hand
                      various prophylactic and therapeutic options including
                      vaccination approaches and the transfer of virus-specific T
                      cells. Such approaches have already been proven to be
                      effective against various viral infections, particularly in
                      immunocompromised patients lacking sufficient humoral,
                      antibody-based immune response. This review provides an
                      overview on the state of the art as well as current studies
                      regarding the identification and characterization of viral
                      T-cell epitopes and approaches of clinical application. In
                      the first chapter in silico prediction tools and direct,
                      mass spectrometry-based identification of viral T-cell
                      epitopes is compared. The second chapter provides an
                      overview of commonly used assays for further
                      characterization of T-cell responses and phenotypes. The
                      final chapter presents an overview of clinical application
                      of viral T-cell epitopes with a focus on human
                      immunodeficiency virus (HIV), human cytomegalovirus (HCMV)
                      and severe acute respiratory syndrome coronavirus type 2
                      (SARS-CoV-2), being representatives of relevant viruses.},
      subtyp        = {Review Article},
      keywords     = {DC vaccination (Other) / Immunopeptidomics (Other) / In
                      silico prediction (Other) / Mass spectrometry (Other) /
                      Peptide vaccination (Other) / T-cell assays (Other) / T-cell
                      epitope characterization (Other) / T-cell epitopes (Other) /
                      T-cell transfer (Other) / Viral infection (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36706520},
      doi          = {10.1016/j.smim.2023.101725},
      url          = {https://inrepo02.dkfz.de/record/212537},
}