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@ARTICLE{Mao:212552,
      author       = {Z. Mao and J. R. Baker and M. Takeuchi and H. Hyogo and A.
                      Tjønneland and A. K. Eriksen and G. Severi and J. Rothwell
                      and N. Laouali and V. Katzke$^*$ and R. Kaaks$^*$ and M. B.
                      Schulze and D. Palli and S. Sieri and M. S. de Magistris and
                      R. Tumino and C. Sacerdote and J. W. G. Derksen and I. T.
                      Gram and G. Skeie and T. M. Sandanger and J. R. Quirós and
                      M. Crous-Bou and M.-J. Sánchez and P. Amiano and S. M.
                      Colorado-Yohar and M. Guevara and S. Harlid and I. Johansson
                      and A. Perez-Cornago and H. Freisling and M. Gunter and E.
                      Weiderpass and A. K. Heath and E. Aglago and M. Jenab and V.
                      Fedirko},
      title        = {{P}re-diagnostic {S}erum {G}lyceraldehyde-{D}erived
                      {A}dvanced {G}lycation {E}nd {P}roducts and {M}ortality
                      {A}mong {C}olorectal {C}ancer {P}atients.},
      journal      = {International journal of cancer},
      volume       = {152},
      number       = {11},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-00237},
      pages        = {2257-2268},
      year         = {2023},
      note         = {2023 Jun 1;152(11):2257-2268},
      abstract     = {Glyceraldehyde-derived advanced glycation end products
                      (glycer-AGEs) could contribute to colorectal cancer
                      development and progression due to their pro-oxidative and
                      pro-inflammatory properties. However, the association of
                      glycer-AGEs with mortality after colorectal cancer diagnosis
                      has not been previously investigated. Circulating
                      glycer-AGEs were measured by competitive ELISA.
                      Multivariable Cox proportional hazards models were used to
                      calculate hazard ratios (HRs) and corresponding $95\%$
                      confidence intervals (CIs) for associations of circulating
                      glycer-AGEs concentrations with CRC-specific and all-cause
                      mortality among 1,034 colorectal cancer (CRC) cases
                      identified within the European Prospective Investigation
                      into Cancer and Nutrition (EPIC) study between 1993 and
                      2013. During a mean of 48 months of follow-up, 529
                      participants died (409 from CRC). Glycer-AGEs were
                      statistically significantly positively associated with
                      CRC-specific (HRQ5 vs Q1 =1.53, $95\%CI:$ 1.04-2.25, Ptrend
                      =0.002) and all-cause (HRQ5 vs Q1 =1.62, $95\%CI:$
                      1.16-2.26, Ptrend <0.001) mortality among individuals with
                      CRC. There was suggestion of a stronger association between
                      glycer-AGEs and CRC-specific mortality among patients with
                      distal colon cancer (per SD increment: HRproximal colon
                      =1.02, $95\%CI:$ 0.74-1.42; HRdistal colon =1.51, $95\%CI:$
                      1.20-1.91; Peffect modification =0.02). The highest HR was
                      observed among CRC cases in the highest body mass index
                      (BMI) and glycer-AGEs category relative to lowest BMI and
                      glycer-AGEs category for both CRC-specific (HR=1.78,
                      $95\%CI:$ 1.02-3.01) and all-cause mortality (HR=2.15,
                      $95\%CI:$ 1.33-3.47), although no statistically significant
                      effect modification was observed. Our study found that
                      pre-diagnostic circulating glycer-AGEs are positively
                      associated with CRC-specific and all-cause mortality among
                      individuals with CRC. Further investigations in other
                      populations and stratifying by tumor location and BMI are
                      warranted. This article is protected by copyright. All
                      rights reserved.},
      keywords     = {Glyceraldehyde-derived advanced glycation end products
                      (Other) / advanced glycation end products (Other) /
                      colorectal cancer (Other) / mortality (Other) / prospective
                      study (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36715363},
      doi          = {10.1002/ijc.34449},
      url          = {https://inrepo02.dkfz.de/record/212552},
}