Journal Article

DKFZ-2023-00237

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pre-diagnostic Serum Glyceraldehyde-Derived Advanced Glycation End Products and Mortality Among Colorectal Cancer Patients.

Mao, Z. ; Baker, J. R. ; Takeuchi, M. ; Hyogo, H. ; Tjønneland, A. ; Eriksen, A. K. ; Severi, G. ; Rothwell, J. ; Laouali, N. ; Katzke, V.DKFZ* ; Kaaks, R.DKFZ* ; Schulze, M. B. ; Palli, D. ; Sieri, S. ; de Magistris, M. S. ; Tumino, R. ; Sacerdote, C. ; Derksen, J. W. G. ; Gram, I. T. ; Skeie, G. ; Sandanger, T. M. ; Quirós, J. R. ; Crous-Bou, M. ; Sánchez, M.-J. ; Amiano, P. ; Colorado-Yohar, S. M. ; Guevara, M. ; Harlid, S. ; Johansson, I. ; Perez-Cornago, A. ; Freisling, H. ; Gunter, M. ; Weiderpass, E. ; Heath, A. K. ; Aglago, E. ; Jenab, M. ; Fedirko, V.

2023
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.34449

Abstract: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1,034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 =1.53, 95%CI: 1.04-2.25, Ptrend =0.002) and all-cause (HRQ5 vs Q1 =1.62, 95%CI: 1.16-2.26, Ptrend <0.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon =1.02, 95%CI: 0.74-1.42; HRdistal colon =1.51, 95%CI: 1.20-1.91; Peffect modification =0.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR=1.78, 95%CI: 1.02-3.01) and all-cause mortality (HR=2.15, 95%CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that pre-diagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted. This article is protected by copyright. All rights reserved.

Keyword(s): Glyceraldehyde-derived advanced glycation end products ; advanced glycation end products ; colorectal cancer ; mortality ; prospective study

Note: 2023 Jun 1;152(11):2257-2268

---

Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---