Journal Article

DKFZ-2023-00241

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Customized 3D-printed molds for high dose-ratebrachytherapy in facial skin cancer: First clinical experience.[3D-gedruckte Moulagen für die individualisierte HDR-Brachytherapie kutaner Malignome im Gesichtsbereich: Erste klinische Erfahrungen.]

Chatzikonstantinou, G. ; Diefenhardt, M. ; Fleischmann, M. ; Meissner, M. ; Scherf, C. ; Trommel, M. ; Ramm, U. ; Rödel, C.DKFZ* ; Tselis, N. ; Licher, J.

2023
Wiley-Blackwell Berlin

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Please use a persistent id in citations: doi:10.1111/ddg.14944_g

Abstract: Background and Objective: Radiotherapy of elderly, frail patients with facial skin cancer in proximity to critical organs is challenging. This is the first report on clinical experience with facial skin cancer treated by individualized 3D-printer-basedmold high-dose-rate (HDR) brachytherapy (BT). Patients and Methods: Fifteen patients not eligible for radical surgery or definitive external beam radiotherapy (EBRT) were treated with 3D-printer-based moldHDR-BT. Patient selection and treatment were in accordance with multidisciplinary tumor board recommendations. Clinicalresponse, toxicity and cosmesis were analyzed. Results: Median age was 77 years. Histology revealed squamous cell carcinomain seven, basal cell carcinoma in five, melanoma in situ in one, Lentigo maligna in one, and melanoma in one patient, respectively. Median prescription dosewas 39 Gy delivered in once-daily fractions of 3 Gy. After a median follow-up of 12.2 months, local recurrence was observed in one patient with melanoma in situ. Apart from one grade 4 cataract, no other >grade 2 late toxicity was documented. Conclusions: HDR-BT with 3D-printer-based molds for facial skin cancer is a well-tolerated and safe treatment option for elderly, frail patients not eligible for radicalsurgery or definitive EBRT due to functional inoperability or tumor location.

Note: english version: Doi:10.1111/ddg.14944

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Frankfurt (FM01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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