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@ARTICLE{Chen:241153,
      author       = {X. Chen$^*$ and T. Heisser$^*$ and R. Cardoso$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{O}verall and age-specific risk advancement periods of
                      colorectal cancer for men versus women: implications for
                      gender-sensitive screening offers?},
      journal      = {International journal of cancer},
      volume       = {153},
      number       = {3},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-00261},
      pages        = {547-551},
      year         = {2023},
      note         = {#EA:C070#LA:C070#LA:C120# / 2023 Aug 1;153(3):547-551},
      abstract     = {Colorectal cancer (CRC) incidence and mortality are higher
                      among men than among women. We aimed to estimate overall and
                      age-specific risk advancement periods (RAPs) for men
                      compared to women, which quantify how many years earlier
                      comparable levels of risk are reached by men. RAPs were
                      derived by Cox regression models among 331,224 participants
                      aged 40-69 at baseline of the UK Biobank with no previous
                      diagnosis of CRC and no previous CRC screening examination
                      who were followed with respect to CRC incidence for up to 13
                      years. Men were at substantially higher risk of CRC than
                      women in age groups 50-59 and 60-69, with RAPs $(95\%$
                      confidence intervals) as high as 8.7 (4.5-13.0) and 6.2
                      (4.5-7.9), respectively. These RAPs were higher than those
                      for family history of CRC in these age groups. By contrast,
                      no significant sex difference but a major impact of family
                      history was seen in age group 40-49 (p-value for interaction
                      between sex and age = 0.00079). The observed patterns
                      suggest that consideration of gender-specific starting ages
                      of screening might be warranted in countries in which
                      screening offers start at ages above 50 years.},
      keywords     = {colorectal cancer (Other) / family history (Other) / risk
                      advancement period (Other) / sex (Other)},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36727542},
      doi          = {10.1002/ijc.34455},
      url          = {https://inrepo02.dkfz.de/record/241153},
}