Journal Article

DKFZ-2023-00261

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Overall and age-specific risk advancement periods of colorectal cancer for men versus women: implications for gender-sensitive screening offers?

Chen, X. (First author)DKFZ* ; Heisser, T.DKFZ* ; Cardoso, R.DKFZ* ; Hoffmeister, M.DKFZ* ; Brenner, H. (Last author)DKFZ*

2023
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.34455

Abstract: Colorectal cancer (CRC) incidence and mortality are higher among men than among women. We aimed to estimate overall and age-specific risk advancement periods (RAPs) for men compared to women, which quantify how many years earlier comparable levels of risk are reached by men. RAPs were derived by Cox regression models among 331,224 participants aged 40-69 at baseline of the UK Biobank with no previous diagnosis of CRC and no previous CRC screening examination who were followed with respect to CRC incidence for up to 13 years. Men were at substantially higher risk of CRC than women in age groups 50-59 and 60-69, with RAPs (95% confidence intervals) as high as 8.7 (4.5-13.0) and 6.2 (4.5-7.9), respectively. These RAPs were higher than those for family history of CRC in these age groups. By contrast, no significant sex difference but a major impact of family history was seen in age group 40-49 (p-value for interaction between sex and age = 0.00079). The observed patterns suggest that consideration of gender-specific starting ages of screening might be warranted in countries in which screening offers start at ages above 50 years.

Keyword(s): colorectal cancer ; family history ; risk advancement period ; sex

Note: #EA:C070#LA:C070#LA:C120# / 2023 Aug 1;153(3):547-551

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Contributing Institute(s):

1. Präventive Onkologie (C120)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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