Journal Article

DKFZ-2023-00276

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study.

Castro-Espin, C. ; Bonet, C. ; Crous-Bou, M. ; Katzke, V.DKFZ* ; Le Cornet, C. ; Jannasch, F. ; Schulze, M. B. ; Olsen, A. ; Tjønneland, A. ; Dahm, C. C. ; Antoniussen, C. S. ; Sánchez, M. J. ; Amiano, P. ; Chirlaque, M. D. ; Guevara, M. ; Agnoli, C. ; Tumino, R. ; Sacerdote, C. ; De Magistris, M. S. ; Sund, M. ; Bodén, S. ; Jensen, T. E. ; Olsen, K. S. ; Skeie, G. ; Gunter, M. J. ; Rinaldi, S. ; Gonzalez-Gil, E. M. ; Weiderpass, E. ; Christakoudi, S. ; Heath, A. K. ; Dossus, L. ; Agudo, A.

2023
Nature Publ. Group Edinburgh

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Please use a persistent id in citations: doi:10.1038/s41416-023-02169-2

Abstract: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

Note: 2023 Mar;128(7):1301-1310

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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