%0 Journal Article
%A Kersting, David
%A Jentzen, Walter
%A Jeromin, Daniel
%A Mavroeidi, Ilektra-Antonia
%A Conti, Maurizio
%A Büther, Florian
%A Herrmann, Ken
%A Rischpler, Christoph
%A Hamacher, Rainer
%A Fendler, Wolfgang P
%A Seifert, Robert
%A Costa, Pedro Fragoso
%T Lesion Quantification Accuracy of Digital 90Y PET Imaging in the Context of Dosimetry in Systemic Fibroblast Activation Protein Inhibitor Radionuclide Therapy.
%J Journal of nuclear medicine
%V 64
%N 2
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2023-00279
%P 329 - 336
%D 2023
%X Therapy with 90Y-labeled fibroblast activation protein inhibitors (90Y-FAPIs) was recently introduced as a novel treatment concept for patients with solid tumors. Lesion and organ-at-risk dosimetry is part of assessing treatment efficacy and safety and requires reliable quantification of tissue uptake. As 90Y quantification is limited by the low internal positron-electron pair conversion rate, the increased effective sensitivity of digital silicon photomultiplier-based PET/CT systems might increase quantification accuracy and, consequently, allow for dosimetry in 90Y-FAPI therapy. The aim of this study was to explore the conditions for reliable lesion image quantification in 90Y-FAPI radionuclide therapy using a digital PET/CT system. Methods: Two tumor phantoms were filled with 90Y solution using different sphere activity concentrations and a constant signal-to-background ratio of 40. The minimum detectable activity concentration was determined, and its dependence on acquisition time (15 vs. 30 min per bed position) and smoothing levels (all-pass vs. 5-mm gaussian filter) was investigated. Quantification accuracy was evaluated at various activity concentrations to estimate the minimum quantifiable activity concentration using contour-based and oversized volume-of-interest-based quantification approaches. A ±20
%K Humans
%K Positron Emission Tomography Computed Tomography
%K Yttrium Radioisotopes: therapeutic use
%K Positron-Emission Tomography: methods
%K Neoplasms: diagnostic imaging
%K Neoplasms: radiotherapy
%K Neoplasms: drug therapy
%K Fibroblasts
%K Gallium Radioisotopes
%K 90Y (Other)
%K FAPI therapy (Other)
%K PET (Other)
%K minimum detectable activity (Other)
%K quantification accuracy (Other)
%K Yttrium Radioisotopes (NLM Chemicals)
%K Gallium Radioisotopes (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35981898
%R 10.2967/jnumed.122.264338
%U https://inrepo02.dkfz.de/record/265117