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@ARTICLE{Shoji:265698,
      author       = {K. F. Shoji and E. Bayet and S. Leverrier-Penna and D. Le
                      Devedec and A. Mallavialle and S. Marionneau-Lambot and F.
                      Rambow$^*$ and R. Perret and A. Joussaume and R. Viel and A.
                      Fautrel and A. Khammari and B. Constantin and S.
                      Tartare-Deckert and A. Penna},
      title        = {{T}he mechanosensitive {TRPV}2 calcium channel promotes
                      human melanoma invasiveness and metastatic potential.},
      journal      = {EMBO reports},
      volume       = {24},
      number       = {4},
      issn         = {1469-221X},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-00293},
      pages        = {e55069},
      year         = {2023},
      note         = {2023 Apr 5;24(4):e55069},
      abstract     = {Melanoma is a highly aggressive cancer endowed with a
                      unique capacity of rapidly metastasizing, which is
                      fundamentally driven by aberrant cell motility behaviors.
                      Discovering 'migrastatics' targets, specifically controlling
                      invasion and dissemination of melanoma cells during
                      metastasis, is therefore of primary importance. Here, we
                      uncover the prominent expression of the plasma membrane
                      TRPV2 calcium channel as a distinctive feature of melanoma
                      tumors, directly related to melanoma metastatic
                      dissemination. In vitro as well as in vivo, TRPV2 activity
                      is sufficient to confer both migratory and invasive
                      potentials, while conversely TRPV2 silencing in highly
                      metastatic melanoma cells prevents aggressive behavior. In
                      invasive melanoma cells, TRPV2 channel localizes at the
                      leading edge, in dynamic nascent adhesions, and regulates
                      calcium-mediated activation of calpain and the ensuing
                      cleavage of the adhesive protein talin, along with F-actin
                      organization. In human melanoma tissues, TRPV2
                      overexpression correlates with advanced malignancy and poor
                      prognosis, evoking a biomarker potential. Hence, by
                      regulating adhesion and motility, the mechanosensitive TRPV2
                      channel controls melanoma cell invasiveness, highlighting a
                      new therapeutic option for migrastatics in the treatment of
                      metastatic melanoma.},
      keywords     = {TRPV2 channel (Other) / calpain (Other) / melanoma (Other)
                      / metastasis (Other) / migration (Other)},
      cin          = {ED01},
      ddc          = {570},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36744297},
      doi          = {10.15252/embr.202255069},
      url          = {https://inrepo02.dkfz.de/record/265698},
}