Journal Article

DKFZ-2023-00293

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.

Shoji, K. F. ; Bayet, E. ; Leverrier-Penna, S. ; Le Devedec, D. ; Mallavialle, A. ; Marionneau-Lambot, S. ; Rambow, F.DKFZ* ; Perret, R. ; Joussaume, A. ; Viel, R. ; Fautrel, A. ; Khammari, A. ; Constantin, B. ; Tartare-Deckert, S. ; Penna, A.

2023
Wiley Hoboken, NJ [u.a.]

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Please use a persistent id in citations: doi:10.15252/embr.202255069

Abstract: Melanoma is a highly aggressive cancer endowed with a unique capacity of rapidly metastasizing, which is fundamentally driven by aberrant cell motility behaviors. Discovering 'migrastatics' targets, specifically controlling invasion and dissemination of melanoma cells during metastasis, is therefore of primary importance. Here, we uncover the prominent expression of the plasma membrane TRPV2 calcium channel as a distinctive feature of melanoma tumors, directly related to melanoma metastatic dissemination. In vitro as well as in vivo, TRPV2 activity is sufficient to confer both migratory and invasive potentials, while conversely TRPV2 silencing in highly metastatic melanoma cells prevents aggressive behavior. In invasive melanoma cells, TRPV2 channel localizes at the leading edge, in dynamic nascent adhesions, and regulates calcium-mediated activation of calpain and the ensuing cleavage of the adhesive protein talin, along with F-actin organization. In human melanoma tissues, TRPV2 overexpression correlates with advanced malignancy and poor prognosis, evoking a biomarker potential. Hence, by regulating adhesion and motility, the mechanosensitive TRPV2 channel controls melanoma cell invasiveness, highlighting a new therapeutic option for migrastatics in the treatment of metastatic melanoma.

Keyword(s): TRPV2 channel ; calpain ; melanoma ; metastasis ; migration

Note: 2023 Apr 5;24(4):e55069

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Contributing Institute(s):

1. DKTK ED ES zentral (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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