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000267530 1001_ $$00000-0002-0442-3284$$aAglago, Elom K$$b0
000267530 245__ $$aDietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study.
000267530 260__ $$aEdinburgh$$bNature Publ. Group$$c2023
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000267530 500__ $$a2023 Apr;128(8):1529-1540
000267530 520__ $$aIron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q1:0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q1:0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q1:1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q1:1.11, 95%CI:0.94, 1.31), heme (HRQ5vs.Q1:0.95; 95%CI:0.84, 1.07) or non-heme iron (HRQ5vs.Q1:1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99).Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.
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000267530 7001_ $$aCross, Amanda J$$b1
000267530 7001_ $$00000-0001-6795-6080$$aRiboli, Elio$$b2
000267530 7001_ $$aFedirko, Veronika$$b3
000267530 7001_ $$aHughes, David J$$b4
000267530 7001_ $$aFournier, Agnes$$b5
000267530 7001_ $$aJakszyn, Paula$$b6
000267530 7001_ $$00000-0001-8648-4998$$aFreisling, Heinz$$b7
000267530 7001_ $$aGunter, Marc J$$b8
000267530 7001_ $$00000-0003-0481-2893$$aDahm, Christina C$$b9
000267530 7001_ $$aOvervad, Kim$$b10
000267530 7001_ $$aTjønneland, Anne$$b11
000267530 7001_ $$aKyrø, Cecilie$$b12
000267530 7001_ $$aBoutron-Ruault, Marie-Christine$$b13
000267530 7001_ $$aRothwell, Joseph A$$b14
000267530 7001_ $$aSeveri, Gianluca$$b15
000267530 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b16$$udkfz
000267530 7001_ $$0P:(DE-He78)0644671d309776d45e0fc705d1156cac$$aSrour, Bernard$$b17
000267530 7001_ $$aSchulze, Matthias B$$b18
000267530 7001_ $$aWittenbecher, Clemens$$b19
000267530 7001_ $$00000-0002-5558-2437$$aPalli, Domenico$$b20
000267530 7001_ $$aSieri, Sabina$$b21
000267530 7001_ $$aPasanisi, Fabrizio$$b22
000267530 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b23
000267530 7001_ $$00000-0001-8749-9737$$aRicceri, Fulvio$$b24
000267530 7001_ $$aBueno-de-Mesquita, Bas$$b25
000267530 7001_ $$aDerksen, Jeroen W G$$b26
000267530 7001_ $$aSkeie, Guri$$b27
000267530 7001_ $$aJensen, Torill Enget$$b28
000267530 7001_ $$aLukic, Marko$$b29
000267530 7001_ $$aSánchez, Maria-Jose$$b30
000267530 7001_ $$aAmiano, Pilar$$b31
000267530 7001_ $$aColorado-Yohar, Sandra$$b32
000267530 7001_ $$aBarricarte, Aurelio$$b33
000267530 7001_ $$aEricson, Ulrika$$b34
000267530 7001_ $$avan Guelpen, Bethany$$b35
000267530 7001_ $$aPapier, Keren$$b36
000267530 7001_ $$aKnuppel, Anika$$b37
000267530 7001_ $$aCasagrande, Corinne$$b38
000267530 7001_ $$00000-0003-3838-855X$$aHuybrechts, Inge$$b39
000267530 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b40
000267530 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b41
000267530 7001_ $$00000-0002-0573-1852$$aJenab, Mazda$$b42
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